Christopher Trent Brewer
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Explore the profile of Christopher Trent Brewer including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
41
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Recent Articles
1.
Brewer C, Kodali K, Wu J, Shaw T, Peng J, Chen T
Cells
. 2020 Jul;
9(7).
PMID: 32660103
Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of...
2.
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis
Brewer C, Yang L, Edwards A, Lu Y, Low J, Wu J, et al.
Toxicol Sci
. 2018 Dec;
168(1):209-224.
PMID: 30517741
In a mouse model, rifampicin and isoniazid combination treatment results in cholestatic liver injury that is associated with an increase in protoporphyrin IX, the penultimate heme precursor. Both ferrochelatase (FECH/Fech)...
3.
Brewer C, Chen T
Int J Mol Sci
. 2017 Nov;
18(11).
PMID: 29117101
Herbal supplements are a significant source of drug-drug interactions (DDIs), herb-drug interactions, and hepatotoxicity. Cytochrome P450 (CYP450) enzymes metabolize a large number of FDA-approved pharmaceuticals and herbal supplements. This metabolism...