Christopher R Neal
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Explore the profile of Christopher R Neal including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
399
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Recent Articles
1.
Hilditch A, Romanyuk A, Hodgson L, Mantell J, Neal C, Verkade P, et al.
J Am Chem Soc
. 2024 Apr;
146(15):10240-10245.
PMID: 38578222
Cellular compartments formed by biomolecular condensation are widespread features of cell biology. These organelle-like assemblies compartmentalize macromolecules dynamically within the crowded intracellular environment. However, the intermolecular interactions that produce condensed...
2.
Gyarmati G, Shroff U, Riquier-Brison A, Kriz W, Kaissling B, Neal C, et al.
Am J Physiol Renal Physiol
. 2021 Jan;
320(3):F492-F504.
PMID: 33491562
Although macula densa (MD) cells are chief regulatory cells in the nephron with unique microanatomical features, they have been difficult to study in full detail due to their inaccessibility and...
3.
Stevens M, Neal C, Craciun E, Dronca M, Harper S, Oltean S
PLoS One
. 2019 Mar;
14(3):e0212910.
PMID: 30865689
There is evidence to suggest that abnormal angiogenesis, inflammation, and fibrosis drive diabetic nephropathy (DN). However, there is no specific treatment to counteract these processes. We aimed to determine whether...
4.
Fabre-Gray A, Down C, Neal C, Foster R, Satchell S, Bills V
Placenta
. 2019 Jan;
74:59-61.
PMID: 30616903
There is a significant glycocalyx present at the maternal-fetal interface of the human placenta, with increasing evidence to suggest it has an important role in placental function. Glycocalyx is adversely...
5.
Neal C, Arkill K, Bell J, Betteridge K, Bates D, Winlove C, et al.
Am J Physiol Renal Physiol
. 2018 Jun;
315(5):F1370-F1384.
PMID: 29923763
To investigate human glomerular structure under conditions of physiological perfusion, we have analyzed fresh and perfusion-fixed normal human glomeruli at physiological hydrostatic and oncotic pressures using serial resin section reconstruction,...
6.
Desideri S, L Onions K, Qiu Y, D Ramnath R, Butler M, Neal C, et al.
Kidney Int
. 2018 Feb;
93(5):1086-1097.
PMID: 29433915
Increased urinary albumin excretion is a key feature of glomerular disease but has limitations as a measure of glomerular permeability. Here we describe a novel assay to measure the apparent...
7.
Stevens M, Neal C, Salmon A, Bates D, Harper S, Oltean S
Nephron
. 2018 Feb;
139(1):51-62.
PMID: 29393270
Background/aims: Genetic cell ablation using the human diphtheria toxin receptor (hDTR) is a new strategy used for analysing cellular function. Diphtheria toxin (DT) is a cytotoxic protein that leaves mouse...
8.
Stevens M, Neal C, Salmon A, Bates D, Harper S, Oltean S
J Physiol
. 2017 Jun;
595(19):6281-6298.
PMID: 28574576
Key Points: Progressive depletion of all vascular endothelial growth factor A (VEGF-A) splice isoforms from the kidney results in proteinuria and increased glomerular water permeability, which are both rescued by...
9.
Betteridge K, Arkill K, Neal C, Harper S, Foster R, Satchell S, et al.
J Physiol
. 2017 May;
595(15):5015-5035.
PMID: 28524373
Key Points: We have developed novel techniques for paired, direct, real-time in vivo quantification of endothelial glycocalyx structure and associated microvessel permeability. Commonly used imaging and analysis techniques yield measurements...
10.
Schulte K, Berger K, Boor P, Jirak P, Gelman I, Arkill K, et al.
J Am Soc Nephrol
. 2013 Sep;
25(1):129-41.
PMID: 24071005
Parietal podocytes are fully differentiated podocytes lining Bowman's capsule where normally only parietal epithelial cells (PECs) are found. Parietal podocytes form throughout life and are regularly observed in human biopsies,...