Christopher R L Large
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Explore the profile of Christopher R L Large including associated specialties, affiliations and a list of published articles.
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7
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44
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Recent Articles
1.
Ridges J, Bladen J, King T, Brown N, Large C, Cooper J, et al.
bioRxiv
. 2024 Jun;
PMID: 38895353
Intra-genomic conflict driven by selfish chromosomes is a powerful force that shapes the evolution of genomes and species. In the male germline, many selfish chromosomes bias transmission in their own...
2.
Martin R, Espinoza C, Large C, Rosswork J, Van Bruinisse C, Miller A, et al.
PLoS Genet
. 2024 Jan;
20(1):e1010850.
PMID: 38175823
Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been...
3.
Taylor M, Skophammer R, Warwick A, Geck R, Boyer J, Walson M, et al.
G3 (Bethesda)
. 2022 Sep;
12(11).
PMID: 36173330
Antifungal resistance in pathogenic fungi is a growing global health concern. Nonpathogenic laboratory strains of Saccharomyces cerevisiae are an important model for studying mechanisms of antifungal resistance that are relevant...
4.
Walker M, Watson T, Large C, Berkovich Y, Lang T, Dunham M, et al.
FEMS Yeast Res
. 2022 Apr;
22(1).
PMID: 35472090
In winemaking, slow or stuck alcoholic fermentation can impact processing efficiency and wine quality. Residual fructose in the later stages of fermentation can leave the wine 'out of specification' unless...
5.
Koonthongkaew J, Toyokawa Y, Ohashi M, Large C, Dunham M, Takagi H
Appl Microbiol Biotechnol
. 2020 Aug;
104(18):7915-7925.
PMID: 32776205
In the yeast Saccharomyces cerevisiae, the mitochondrial branched-chain amino acid (BCAA) aminotransferase Bat1 plays an important role in the synthesis of BCAAs (valine, leucine, and isoleucine). Our upcoming study (Large...
6.
Smukowski Heil C, Large C, Patterson K, Hickey A, Yeh C, Dunham M
PLoS Genet
. 2019 Sep;
15(9):e1008383.
PMID: 31525194
Interspecific hybridization can introduce genetic variation that aids in adaptation to new or changing environments. Here, we investigate how hybrid adaptation to temperature and nutrient limitation may alter parental genome...
7.
Sanchez J, Ollodart A, Large C, Clough C, Alvino G, Tsuchiya M, et al.
Genetics
. 2019 Jul;
213(1):229-249.
PMID: 31292210
The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest...