Christopher P Lapointe
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Explore the profile of Christopher P Lapointe including associated specialties, affiliations and a list of published articles.
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20
Citations
533
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Recent Articles
1.
Gen R, Addetia A, Asarnow D, Park Y, Quispe J, Chan M, et al.
bioRxiv
. 2025 Jan;
PMID: 39868184
SARS-CoV-2 nonstructural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 in other host species remains elusive, especially in bats...
2.
Grosely R, Alvarado C, Ivanov I, Nicholson O, Puglisi J, Dever T, et al.
bioRxiv
. 2024 Jul;
PMID: 39026837
Translation initiation defines the identity of a synthesized protein through selection of a translation start site on a messenger RNA. This process is essential to well-controlled protein synthesis, modulated by...
3.
Schubert K, Karousis E, Ban I, Lapointe C, Leibundgut M, Baumlin E, et al.
Mol Cell
. 2023 Oct;
83(19):3546-3557.e8.
PMID: 37802027
Nonstructural protein 1 (Nsp1) produced by coronaviruses inhibits host protein synthesis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp1 C-terminal domain was shown to bind the ribosomal mRNA channel...
4.
Hentschel J, Badstubner M, Choi J, Bagshaw C, Lapointe C, Wang J, et al.
Biophys J
. 2023 Jul;
122(17):3447-3457.
PMID: 37515327
Genomic stability in proliferating cells critically depends on telomere maintenance by telomerase reverse transcriptase. Here we report the development and proof-of-concept results of a single-molecule approach to monitor the catalytic...
5.
Schubert K, Karousis E, Ban I, Lapointe C, Leibundgut M, Baumlin E, et al.
bioRxiv
. 2023 Jul;
PMID: 37398176
Nonstructural protein 1 (Nsp1) produced by coronaviruses shuts down host protein synthesis in infected cells. The C-terminal domain of SARS-CoV-2 Nsp1 was shown to bind to the small ribosomal subunit...
6.
Lapointe C, Grosely R, Sokabe M, Alvarado C, Wang J, Montabana E, et al.
Nature
. 2022 Jun;
607(7917):185-190.
PMID: 35732735
Translation initiation defines the identity and quantity of a synthesized protein. The process is dysregulated in many human diseases. A key commitment step is when the ribosomal subunits join at...
7.
Lapointe C, Grosely R, Johnson A, Wang J, Fernandez I, Puglisi J
Proc Natl Acad Sci U S A
. 2021 Jan;
118(6).
PMID: 33479166
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A molecular framework of...
8.
Medina-Munoz H, Lapointe C, Porter D, Wickens M
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23539-23547.
PMID: 32907940
RNA movements and localization pervade biology, from embryonic development to disease. To identify RNAs at specific locations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular...
9.
Johnson A, Flynn R, Lapointe C, Ooi Y, Zhao M, Richards C, et al.
Nucleic Acids Res
. 2020 May;
48(13):7279-7297.
PMID: 32463448
In order to maintain cellular protein homeostasis, ribosomes are safeguarded against dysregulation by myriad processes. Remarkably, many cell types can withstand genetic lesions of certain ribosomal protein genes, some of...
10.
Wang J, Johnson A, Lapointe C, Choi J, Prabhakar A, Chen D, et al.
Nature
. 2019 Sep;
573(7775):605-608.
PMID: 31534220
Translation initiation determines both the quantity and identity of the protein that is encoded in an mRNA by establishing the reading frame for protein synthesis. In eukaryotic cells, numerous translation...