Christopher Meehan
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Explore the profile of Christopher Meehan including associated specialties, affiliations and a list of published articles.
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16
Citations
216
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Recent Articles
1.
Pang R, Meehan C, Maple G, Norris G, Campbell E, Tucker K, et al.
J Pineal Res
. 2024 May;
76(4):e12962.
PMID: 38775315
There is a need to develop therapies for neonatal encephalopathy (NE) in low- and middle-income countries (LMICs) where the burden of disease is greatest and therapeutic hypothermia (HT) is not...
2.
Abramsky R, Acun C, Alt J, Aly H, Arad N, Baak L, et al.
J Neonatal Perinatal Med
. 2023 Aug;
16(s1):S33-S62.
PMID: 37599542
No abstract available.
3.
Mitra S, Harvey-Jones K, Kraev I, Verma V, Meehan C, Mintoft A, et al.
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511288
Neonatal seizures are commonly associated with acute perinatal brain injury, while understanding regarding the downstream molecular pathways related to seizures remains unclear. Furthermore, effective treatment and reliable biomarkers are still...
4.
Harvey-Jones K, Lange F, Verma V, Bale G, Meehan C, Avdic-Belltheus A, et al.
Pediatr Res
. 2023 Jun;
94(5):1675-1683.
PMID: 37308684
Background: Opportunities for adjunct therapies with cooling in neonatal encephalopathy are imminent; however, robust biomarkers of early assessment are lacking. Using an optical platform of broadband near-infrared spectroscopy and diffuse...
5.
Pang R, Han H, Meehan C, Golay X, Miller S, Robertson N
Ann Clin Transl Neurol
. 2022 Apr;
9(6):795-809.
PMID: 35413154
Objective: Neonatal encephalopathy (NE) is an important cause of mortality and disability worldwide. Therapeutic hypothermia (HT) is an effective therapy, however not all babies benefit. Novel agents are urgently needed...
6.
Pang R, Advic-Belltheus A, Meehan C, Fullen D, Golay X, Robertson N
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34067448
Neonatal encephalopathy is a leading cause of morbidity and mortality worldwide. Although therapeutic hypothermia (HT) is now standard practice in most neonatal intensive care units in high resource settings, some...
7.
Martinello K, Meehan C, Avdic-Belltheus A, Lingam I, Mutshiya T, Yang Q, et al.
Pediatr Res
. 2021 May;
91(6):1416-1427.
PMID: 34050269
Background: Perinatal inflammation combined with hypoxia-ischemia (HI) exacerbates injury in the developing brain. Therapeutic hypothermia (HT) is standard care for neonatal encephalopathy; however, its benefit in inflammation-sensitized HI (IS-HI) is...
8.
Pang R, Avdic-Belltheus A, Meehan C, Martinello K, Mutshiya T, Yang Q, et al.
Brain Commun
. 2021 Feb;
3(1):fcaa211.
PMID: 33604569
As therapeutic hypothermia is only partially protective for neonatal encephalopathy, safe and effective adjunct therapies are urgently needed. Melatonin and erythropoietin show promise as safe and effective neuroprotective therapies. We...
9.
Robertson N, Meehan C, Martinello K, Avdic-Belltheus A, Boggini T, Mutshiya T, et al.
Cytotherapy
. 2020 Dec;
23(6):521-535.
PMID: 33262073
Background: With therapeutic hypothermia (HT) for neonatal encephalopathy, disability rates are reduced, but not all babies benefit. Pre-clinical rodent studies suggest mesenchymal stromal cells (MSCs) augment HT protection. Aims: The...
10.
Pang R, Martinello K, Meehan C, Avdic-Belltheus A, Lingam I, Sokolska M, et al.
Front Neurol
. 2020 Oct;
11:883.
PMID: 33013626
Despite therapeutic hypothermia, survivors of neonatal encephalopathy have high rates of adverse outcome. Early surrogate outcome measures are needed to speed up the translation of neuroprotection trials. Thalamic lactate (Lac)/N-acetylaspartate...