Christopher L Reading
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Explore the profile of Christopher L Reading including associated specialties, affiliations and a list of published articles.
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19
Citations
130
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Recent Articles
1.
Reading C, Ahlem C, Murphy M
Neurodegener Dis Manag
. 2021 Jul;
11(4):289-298.
PMID: 34251287
Recently, the roles of inflammation and insulin resistance in neurodegeneration have become better appreciated. NE3107, an oral small molecule, blood-brain permeable anti-inflammatory insulin sensitizer that binds extracellular signal-regulated kinase, has...
2.
Reading C, Stickney D, Flores-Riveros J, Destiche D, Ahlem C, Cefalu W, et al.
Obesity (Silver Spring)
. 2013 May;
21(9):E343-9.
PMID: 23670958
Objective: To study the activity of HE3286 (17α-ethynylandrost-5-ene-3β,7β,17β-triol), an anti-inflammatory sterol that is active in models of obesity-induced inflammation and insulin resistance in high body mass index (BMI) subjects with...
3.
Nicoletti F, Philippens I, Fagone P, Ahlem C, Reading C, Frincke J, et al.
Parkinsons Dis
. 2012 Oct;
2012:969418.
PMID: 23050197
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy in...
4.
Reading C, Frincke J, White S
PLoS One
. 2012 Mar;
7(2):e32147.
PMID: 22384159
HE3286, 17α-ethynyl-5-androstene-3β, 7β, 17β-triol, is a novel synthetic compound related to the endogenous sterol 5-androstene-3β, 7β, 17β-triol (β-AET), a metabolite of the abundant adrenal steroid dehydroepiandrosterone (DHEA). HE3286 has shown...
5.
Ahlem C, Frincke J, White S, Reading C, Trauger R, Lakshmanaswamy R
Int J Breast Cancer
. 2012 Feb;
2011:618757.
PMID: 22332014
N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in combination...
6.
Ahlem C, Kennedy M, Page T, Reading C, White S, McKenzie J, et al.
Int J Clin Exp Med
. 2011 Jun;
4(2):119-35.
PMID: 21686136
17α-Ethynyl-androst-5ene-3β, 7β, 17β-triol (HE3286) is an orally bioavailable analogue of androst-5-ene-3β,7β,17β-triol, a non-glucocorticoid anti-inflammatory metabolite of the adrenal steroid, dehydroepiandrosterone. The pharmacology of HE3286 was characterized in preparation for clinical...
7.
Stickney D, Ahlem C, Morgan E, Reading C, Onizuka N, Frincke J
Am J Transl Res
. 2011 Jun;
3(3):275-83.
PMID: 21633633
Unlabelled: The immune regulating DHEA metabolite, androst-5-ene-3β,7β,17β-triol (βAET), was evaluated for safety, cholesterol lowering, and vaccine enhancement in phase I and phase II clinical trials. Safety and pharmacokinetics were evaluated...
8.
Ahlem C, Auci D, Nicoletti F, Pieters R, Kennedy M, Page T, et al.
J Steroid Biochem Mol Biol
. 2011 May;
126(3-5):87-94.
PMID: 21570467
Androst-5-ene-3β,7β,17β-triol (βAET) is an anti-inflammatory metabolite of DHEA that is found naturally in humans, but in rodents only after exogenous DHEA administration. Unlike DHEA, C-7-oxidized DHEA metabolites cannot be metabolized...
9.
Kosiewicz M, Auci D, Fagone P, Mangano K, Caponnetto S, Tucker C, et al.
Eur J Pharmacol
. 2011 Mar;
658(2-3):257-62.
PMID: 21371458
5-Androstene-3β,7β,17β-triol (AET) is a naturally occurring anti-inflammatory adrenal steroid that limits acute and chronic inflammation. HE3286 (17α-ethynyl-5-androstene-3β,7β,17β-triol) is a synthetic derivative of AET with improved pharmaceutical properties and efficacy in...
10.
Nicoletti F, Auci D, Mangano K, Flores-Riveros J, Villegas S, Frincke J, et al.
Autoimmune Dis
. 2010 Dec;
2010:757432.
PMID: 21188238
Androstenediol (androst-5-ene-3β,17β-diol; 5-AED), a natural adrenal steroid, has been shown to suppress experimental autoimmune encephalomyelitis (EAE) in female SJL/J mice. We here report that 5-AED limits inflammation and proinflammatory cytokines...