Christopher J Earley
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Explore the profile of Christopher J Earley including associated specialties, affiliations and a list of published articles.
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140
Citations
3451
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Recent Articles
1.
Garcia-Borreguero D, Black J, Earley C, Fulda S, Hogl B, Manconi M, et al.
Sleep Med Rev
. 2024 Aug;
77:101978.
PMID: 39102777
The number of large clinical trials of restless legs syndrome (RLS) have decreased in recent years, this coincides with reduced interest in developing and testing novel pharmaceuticals. Therefore, the International...
2.
Schormair B, Zhao C, Bell S, Didriksen M, Nawaz M, Schandra N, et al.
Nat Genet
. 2024 Jun;
56(6):1090-1099.
PMID: 38839884
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points...
3.
Manolopoulos A, York W, Pucha K, Earley C, Kapogiannis D
Ann Neurol
. 2024 Apr;
96(3):560-564.
PMID: 38646966
Brain iron deficiency (ID) and, to a degree, systemic ID have been implicated in restless leg syndrome (RLS) pathogenesis. Previously, we found increased ferritin in neuron-derived extracellular vesicles (NDEVs) in...
4.
Earley C, Garcia-Borreguero D, Falone M, Winkelman J
Sleep
. 2024 Apr;
47(7).
PMID: 38625730
Study Objectives: Iron therapy is associated with improvements in restless legs syndrome (RLS). This multicenter, randomized, double-blind study evaluated the effect of intravenous ferric carboxymaltose (FCM) on RLS. Methods: A...
5.
Short V, Allen R, Earley C, Bahrain H, Rineer S, Kashi K, et al.
Am J Hematol
. 2024 Mar;
99(6):1077-1083.
PMID: 38476079
Restless legs syndrome (RLS) is a neurological disorder that can have a profound effect on sleep and quality of life. Idiopathic RLS is associated with brain iron insufficiency despite normal...
6.
Gu C, Li Y, Cao D, Miao X, Paez A, Sun Y, et al.
Magn Reson Med
. 2023 Dec;
91(5):1893-1907.
PMID: 38115573
Purpose: The inflow-based vascular-space-occupancy (iVASO) MRI was originally developed in a single-slice mode to measure arterial cerebral blood volume (CBVa). When vascular crushers are applied in iVASO, the signals can...
7.
Ferre S, Winkelman J, Garcia-Borreguero D, Belcher A, Chang J, Earley C
Sleep
. 2023 Oct;
47(3).
PMID: 37864837
Restlessness is a core symptom underlying restless legs syndrome (RLS), neuroleptic-induced akathisia, and opioid withdrawal. These three conditions also share other clinical components suggesting some overlap in their pathophysiology. Recent...
8.
Bae H, Cho Y, Kim K, Li X, Earley C
Sleep Med
. 2023 Jul;
109:128-131.
PMID: 37437492
Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA,...
9.
Ferre S, Belcher A, Bonaventura J, Quiroz C, Sanchez-Soto M, Casado-Anguera V, et al.
Front Endocrinol (Lausanne)
. 2022 Oct;
13:1014678.
PMID: 36267569
The functional and pharmacological significance of the dopamine D receptor (DR) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role...
10.
Earley C, Jones B, Ferre S
Exp Neurol
. 2022 Jul;
356:114158.
PMID: 35779614
Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered dopaminergic system. The ability...