Christopher J Costa
Overview
Explore the profile of Christopher J Costa including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
160
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0
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Recent Articles
1.
Costa C, Prescott S, Fourie N, Abey S, Sherwin L, Rahim-Williams B, et al.
Nutrients
. 2025 Mar;
17(5).
PMID: 40077792
Background: Chronic visceral hypersensitivity is associated with an overstressed pain response to noxious stimuli (hyperalgesia). Microbiota are active modulators of host biology and are implicated in the etiology of visceral...
2.
Costa C, Nguyen M, Vaziri H, Wu G
J Clin Transl Hepatol
. 2024 Mar;
12(3):316-326.
PMID: 38426197
Gallstone (GS) disease is common and arises from a combination of genetic and environmental factors. Although genetic abnormalities specifically leading to cholesterol GSs are rare, there are clinically significant gene...
3.
Joyce R, Tibbs G, Warren J, Costa C, Aromolaran K, Sanford R, et al.
Neurobiol Pain
. 2023 Dec;
14:100141.
PMID: 38099280
2,6-di--butylphenol (2,6-DTBP) ameliorates mechanical allodynia and thermal hyperalgesia produced by partial sciatic nerve ligation in mice, and selectively inhibits HCN1 channel gating. We hypothesized that the clinically utilized non-anesthetic dimerized...
4.
Tibbs G, Uprety R, Warren J, Beyer N, Joyce R, Ferrer M, et al.
Br J Anaesth
. 2023 Aug;
131(4):745-763.
PMID: 37567808
Background: Neuropathic pain impairs quality of life, is widely prevalent, and incurs significant costs. Current pharmacological therapies have poor/no efficacy and significant adverse effects; safe and effective alternatives are needed....
5.
Costa C, Cohen M, Goldberg D, Mellado W, Willis D
Dig Dis Sci
. 2023 Mar;
68(7):2963-2974.
PMID: 36920665
Background: Diabetes Mellitus causes a systemic oxidative stress due in part to the hyperglycemia and the reactive oxygen species generated. Up to 75% of diabetic patients present with an autonomic...
6.
Jones J, Costa C, Cooney C, Goldberg D, Ponticiello M, Cohen M, et al.
Front Mol Neurosci
. 2021 Dec;
14:728163.
PMID: 34949989
Most diabetes patients eventually suffer from peripheral nerve degeneration. Unfortunately, there is no treatment for the condition and its mechanisms are not well understood. There is, however, an emerging consensus...
7.
Picci C, Wong V, Costa C, McKinnon M, Goldberg D, Swift M, et al.
Exp Neurol
. 2020 Mar;
328:113281.
PMID: 32147437
Charcot-Marie-Tooth type 2A (CMT2A) peripheral neuropathy, the most common axonal form of CMT, is caused by dominantly inherited point mutations in the Mitofusin 2 (Mfn2) gene. It is characterized by...
8.
Gershoni-Emek N, Altman T, Ionescu A, Costa C, Gradus-Pery T, Willis D, et al.
Front Mol Neurosci
. 2018 Sep;
11:311.
PMID: 30233312
Local protein synthesis in neuronal axons plays an important role in essential spatiotemporal signaling processes; however, the molecular basis for the post-transcriptional regulation controlling this process in axons is still...
9.
Costa C, Willis D
Dev Neurobiol
. 2017 Nov;
78(3):209-220.
PMID: 29115051
Axons and growth cones, by their very nature far removed from the cell body, encounter unique environments and require distinct populations of proteins. It seems only natural, then, that they...
10.
Rotem N, Magen I, Ionescu A, Gershoni-Emek N, Altman T, Costa C, et al.
Sci Rep
. 2017 Mar;
7:44500.
PMID: 28300211
Amyotrophic lateral sclerosis (ALS) is a multifactorial lethal motor neuron disease with no known treatment. Although the basic mechanism of its degenerative pathogenesis remains poorly understood, a subcellular spatial alteration...