Christopher D Coldren
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Explore the profile of Christopher D Coldren including associated specialties, affiliations and a list of published articles.
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26
Citations
1412
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Recent Articles
1.
Glidewell S, Miyamoto S, Grossfeld P, Clouthier D, Coldren C, Stearman R, et al.
Clin Transl Sci
. 2015 Nov;
8(6):682-9.
PMID: 26534787
Background: Hypoplastic left heart syndrome (HLHS) is a heterogeneous, lethal combination of congenital malformations characterized by severe underdevelopment of left heart structures, resulting in a univentricular circulation. The genetic determinants...
2.
Steele M, Luna L, Coldren C, Murphy E, Hennessy C, Heinz D, et al.
BMC Genomics
. 2015 Oct;
16:869.
PMID: 26503507
Background: Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous, somewhat unpredictable diseases characterized by progressive scarring of the interstitium. Since lung function is a key determinant of survival, we...
3.
Nakachi I, Rice J, Coldren C, Edwards M, Stearman R, Glidewell S, et al.
Cancer Prev Res (Phila)
. 2013 Dec;
7(2):255-65.
PMID: 24346345
Chromosomal instability is central to the process of carcinogenesis. The genome-wide detection of somatic chromosomal alterations (SCA) in small premalignant lesions remains challenging because sample heterogeneity dilutes the aberrant cell...
4.
Bowler R, Bahr T, Hughes G, Lutz S, Kim Y, Coldren C, et al.
OMICS
. 2013 Oct;
17(12):619-26.
PMID: 24138069
Interleukin-16 (IL-16) is a multifunctional cytokine that has been associated with autoimmune and allergic diseases. To investigate comprehensively whether IL-16 is also associated with chronic obstructive pulmonary disease (COPD) and...
5.
Yang I, Coldren C, Leach S, Seibold M, Murphy E, Lin J, et al.
Thorax
. 2013 Jun;
68(12):1114-21.
PMID: 23783374
Background: Idiopathic pulmonary fibrosis (IPF) is an untreatable lung disease with a median survival of only 3-5 years that is diagnosed using a combination of clinical, radiographic and pathologic criteria....
6.
Bahr T, Hughes G, Armstrong M, Reisdorph R, Coldren C, Edwards M, et al.
Am J Respir Cell Mol Biol
. 2013 Apr;
49(2):316-23.
PMID: 23590301
Although most cases of chronic obstructive pulmonary disease (COPD) occur in smokers, only a fraction of smokers develop the disease. We hypothesized distinct molecular signatures for COPD and emphysema in...
7.
Mascaux C, Feser W, Lewis M, Baron A, Coldren C, Merrick D, et al.
Cancer Prev Res (Phila)
. 2012 Dec;
6(2):100-8.
PMID: 23268837
Lung cancers express lower levels of prostacyclin than normal lung tissues. Prostacyclin prevents lung cancer in a variety of mouse models. A randomized phase II trial comparing oral iloprost (a...
8.
Coldren C, Miller Y
Am J Respir Crit Care Med
. 2011 Oct;
184(8):869-70.
PMID: 22003147
No abstract available.
9.
Risbano M, Meadows C, Coldren C, Jenkins T, Edwards M, Collier D, et al.
Clin Transl Sci
. 2010 Oct;
3(5):210-8.
PMID: 20973920
Pulmonary arterial hypertension is a common and fatal complication of scleroderma that may involve inflammatory and autoimmune mechanisms. Alterations in the gene expression of peripheral blood mononuclear cells have been...
10.
Aldred M, Comhair S, Varella-Garcia M, Asosingh K, Xu W, Noon G, et al.
Am J Respir Crit Care Med
. 2010 Jun;
182(9):1153-60.
PMID: 20581168
Rationale: Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial...