Christopher C Wendler
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Explore the profile of Christopher C Wendler including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
302
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Recent Articles
1.
Fang X, Poulsen R, Zhao L, Wang J, Rivkees S, Wendler C
FEBS Open Bio
. 2021 Jul;
11(8):2364-2382.
PMID: 34235895
We previously found that DNA methyltransferase 3a (DNMT3a) plays an important role in regulating embryonic cardiomyocyte gene expression, morphology, and function. In this study, we investigated the role of the...
2.
Rivkees S, Wendler C
Mol Aspects Med
. 2017 Feb;
55:110-117.
PMID: 28202385
There is growing evidence that disruption in the prenatal environment can have long-lasting effects on an individual's health in adulthood. Research on the fetal programming of adult diseases, including cardiovascular...
3.
Fang X, Poulsen R, Rivkees S, Wendler C
Sci Rep
. 2016 Sep;
6:34106.
PMID: 27677355
Each year millions of pregnant woman are exposed to caffeine, which acts to antagonize adenosine action. The long-term consequences of this exposure on the developing fetus are largely unknown, although...
4.
Fang X, Poulsen R, Wang-Hu J, Shi O, Calvo N, Simmons C, et al.
FASEB J
. 2016 Jun;
30(9):3238-55.
PMID: 27306334
We previously found that in utero caffeine exposure causes down-regulation of DNA methyltransferases (DNMTs) in embryonic heart and results in impaired cardiac function in adulthood. To assess the role of...
5.
Strobl M, Freeman D, Patel J, Poulsen R, Wendler C, Rivkees S, et al.
Cereb Cortex
. 2016 May;
27(5):3015-3027.
PMID: 27235101
Insufficient or excessive thyroid hormone (TH) levels during fetal development can cause long-term neurological and cognitive problems. Studies in animal models of perinatal hypo- and hyperthyroidism suggest that these problems...
6.
Fang X, Robinson J, Wang-Hu J, Jiang L, Freeman D, Rivkees S, et al.
Am J Physiol Cell Physiol
. 2015 Jul;
309(6):C425-36.
PMID: 26224577
cAMP is a highly regulated secondary messenger involved in many biological processes. Chronic activation of the cAMP pathway by catecholamines results in cardiac hypertrophy and fibrosis; however, the mechanism by...
7.
Cox M, Wendler C, Erdelyi I, Beck A, Zeiss C, Rivkees S
Online J Biol Sci
. 2015 Jan;
14(1):49-56.
PMID: 25587244
Diazoxide is an ATP-sensitive potassium channel (K) agonist that has been shown to neuroprotective effects. These observations raise the possibility that diazoxide may have potential as a therapeutic agent for...
8.
Fang X, Mei W, Barbazuk W, Rivkees S, Wendler C
Am J Physiol Regul Integr Comp Physiol
. 2014 Oct;
307(12):R1471-87.
PMID: 25354728
Previous studies demonstrated that in utero caffeine treatment at embryonic day (E) 8.5 alters DNA methylation patterns, gene expression, and cardiac function in adult mice. To provide insight into the...
9.
Zhu Y, Wendler C, Shi O, Rivkees S
Brain Res
. 2014 Aug;
1586:64-72.
PMID: 25157906
Periventricular white matter injury (PWMI) is the most common cause of brain injury in preterm infants. It is believed that loss of late oligodendrocyte progenitor cells (OPCs) and disrupted maturation...
10.
Mallela M, Strobl M, Poulsen R, Wendler C, Booth C, Rivkees S
Birth Defects Res B Dev Reprod Toxicol
. 2014 Jul;
101(4):300-7.
PMID: 24980470
Background: Propylthiouracil (PTU) and methimazole (MMI) are antithyroid drugs used to treat hyperthyroidism. Despite the widespread use of PTU and MMI during pregnancy, modest clinical data and less animal data...