Christopher Buccitelli
Overview
Explore the profile of Christopher Buccitelli including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
812
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0
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Recent Articles
1.
Welters C, Lammoglia Cobo M, Stein C, Hsu M, Ben Hamza A, Penter L, et al.
Cancer Immunol Res
. 2022 Sep;
10(11):1407-1419.
PMID: 36122410
Multiple myeloma is a hematologic malignancy of monoclonal plasma cells that accumulate in the bone marrow. Despite their clinical and pathophysiologic relevance, the roles of bone marrow-infiltrating T cells in...
2.
Chunduri N, Menges P, Zhang X, Wieland A, Gotsmann V, Mardin B, et al.
Nat Commun
. 2021 Sep;
12(1):5576.
PMID: 34552071
Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we...
3.
Wyler E, Mosbauer K, Franke V, Diag A, Gottula L, Arsie R, et al.
iScience
. 2021 Feb;
24(3):102151.
PMID: 33585804
Detailed knowledge of the molecular biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host responses, and disease progression. Here, we report...
4.
Buccitelli C, Selbach M
Nat Rev Genet
. 2020 Jul;
21(10):630-644.
PMID: 32709985
Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency...
5.
Salgueiro L, Buccitelli C, Rowald K, Somogyi K, Kandala S, Korbel J, et al.
EMBO Mol Med
. 2020 Feb;
12(3):e10941.
PMID: 32030896
Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is...
6.
Buccitelli C, Salgueiro L, Rowald K, Sotillo R, Mardin B, Korbel J
Genome Res
. 2017 Mar;
27(4):501-511.
PMID: 28320919
Patterns of gene expression in tumors can arise as a consequence of or result in genomic instability, characterized by the accumulation of somatic copy number alterations (SCNAs) and point mutations...
7.
Rowald K, Mantovan M, Passos J, Buccitelli C, Mardin B, Korbel J, et al.
Cell Rep
. 2016 Jun;
15(12):2679-91.
PMID: 27292643
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that...
8.
Mardin B, Drainas A, Waszak S, Weischenfeldt J, Isokane M, Stutz A, et al.
Mol Syst Biol
. 2015 Sep;
11(9):828.
PMID: 26415501
A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one-off genomic catastrophe, resulting in massive somatic DNA structural rearrangements (SRs). Largely due to...