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Christopher B Thomas

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Citations 79
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Recent Articles
1.
Gibbs K, Semler M, Driver B, Seitz K, Stempek S, Taylor C, et al.
N Engl J Med . 2024 Jun; 390(23):2165-2177. PMID: 38869091
Background: Among critically ill adults undergoing tracheal intubation, hypoxemia increases the risk of cardiac arrest and death. The effect of preoxygenation with noninvasive ventilation, as compared with preoxygenation with an...
2.
ONeal Jr H, Sheybani R, Kraus C, Self W, Shah A, Thomas C, et al.
Acad Emerg Med . 2024 Apr; 31(9):883-893. PMID: 38643433
Objectives: Sepsis is one of the most common, costly, and misdiagnosed conditions in U.S. emergency departments (EDs). ED providers often treat on nonspecific signs, subjective suspicion, or presumption of infection,...
3.
ONeal Jr H, Sheybani R, Janz D, Scoggins R, Jagneaux T, Walker J, et al.
Crit Care Explor . 2024 Feb; 6(2):e1026. PMID: 38333076
Objectives: To assess the in vitro IntelliSep test, a microfluidic assay that quantifies the state of immune activation by evaluating the biophysical properties of leukocytes, as a rapid diagnostic for...
4.
Hollenbeak C, Henning D, Geeting G, Ledeboer N, Faruqi I, Pierce C, et al.
Crit Care Explor . 2023 Jul; 5(7):e0942. PMID: 37465702
Perspective: U.S. healthcare system. Setting: Community hospital ED. Methods: A decision tree analysis was performed comparing ISI with procalcitonin. Model parameters included prevalence of sepsis, sensitivity and specificity of diagnostic...
5.
Self W, Wheeler A, Stewart T, Schrager H, Mallada J, Thomas C, et al.
Chest . 2022 Jul; 162(5):982-994. PMID: 35780813
Background: Convalescent plasma has been one of the most common treatments for COVID-19, but most clinical trial data to date have not supported its efficacy. Research Question: Is rigorously selected...
6.
ONeal C, Hamer D, Musso M, Caffery T, Walker M, Lavie K, et al.
Am J Med Sci . 2022 Mar; 364(2):163-167. PMID: 35300978
Background: This study examined three methods for retrospectively identifying infection in emergency department (ED) patients: modified objective definitions of infection (MODI) from the CDC/NHSN, physician adjudication determination of infection, and...
7.
ONeal Jr H, Sheybani R, Caffery T, Hamer D, Laperouse Jr L, Musso M, et al.
PLoS One . 2022 Mar; 17(3):e0264220. PMID: 35294441
Objective: Assess the IntelliSep Index (ISI) for risk stratification of patients presenting to the Emergency Department (ED) with respiratory symptoms suspected of COVID-19 during the pandemic. Methods: An observational single-center...
8.
ONeal Jr H, Sheybani R, Caffery T, Musso M, Hamer D, Alwood S, et al.
Crit Care Explor . 2021 Jun; 3(6):e0460. PMID: 34151282
Objectives: Sepsis is a common cause of morbidity and mortality. A reliable, rapid, and early indicator can help improve efficiency of care and outcomes. To assess the IntelliSep test, a...
9.
Guillou L, Sheybani R, Jensen A, Di Carlo D, Caffery T, Thomas C, et al.
PLoS One . 2021 Apr; 16(4):e0246980. PMID: 33857126
Sepsis must be diagnosed quickly to avoid morbidity and mortality. However, the clinical manifestations of sepsis are highly variable and emergency department (ED) clinicians often must make rapid, impactful decisions...
10.
Sanchez M, Thomas C, ONeal H
Curr Opin Infect Dis . 2012 Mar; 25(3):345-50. PMID: 22395760
Purpose Of Review: Sepsis is an inflammatory condition associated with significant morbidity and mortality. Given the lack of specific therapies for the condition, prevention has garnered significant interest and increased...