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Christoph Wagener

Explore the profile of Christoph Wagener including associated specialties, affiliations and a list of published articles. Areas
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Citations 865
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Recent Articles
1.
Mercanoglu B, Waschkowski S, Neuburg E, Schraps N, Giannou A, Dreyer B, et al.
Sci Rep . 2024 Nov; 14(1):29760. PMID: 39613794
GALNT2, also known as polypeptide N-acetylgalactosaminyltransferase 2, is an enzyme that catalyzes the initial step of O-linked glycosylation, a crucial posttranslational modification that affects protein folding, stability, and function. Alterations...
2.
Wegscheider A, Wojahn I, Gottheil P, Spohn M, Kas J, Rosin O, et al.
Glycobiology . 2024 Jan; 34(3). PMID: 38206856
Glycosylation is a prominent posttranslational modification, and alterations in glycosylation are a hallmark of cancer. Glycan-binding receptors, primarily expressed on immune cells, play a central role in glycan recognition and...
3.
Starzonek S, Maar H, Labitzky V, Wicklein D, Rossdam C, Buettner F, et al.
Glycobiology . 2020 Feb; 30(9):695-709. PMID: 32103235
Endothelial E- and P-selectins promote metastasis formation by interacting with sialyl-Lewis X and A (sLeX/sLeA) on circulating tumor cells. This interaction precedes extravasation and can take place under dynamic and...
4.
Kurze A, Buhs S, Eggert D, Oliveira-Ferrer L, Muller V, Niendorf A, et al.
Cell Commun Signal . 2019 Aug; 17(1):107. PMID: 31455323
Background: Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies. A variety of regulatory mechanisms underlying their...
5.
Horst A, Najjar S, Wagener C, Tiegs G
Int J Mol Sci . 2018 Oct; 19(10). PMID: 30314283
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells. CEACAM1 is a differentiation antigen involved in the maintenance of...
6.
Wolters-Eisfeld G, Mercanoglu B, Hofmann B, Wolpers T, Schnabel C, Harder S, et al.
Exp Mol Med . 2018 Oct; 50(10):1-13. PMID: 30305605
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of...
7.
Schirbel A, Rebert N, Sadler T, West G, Rieder F, Wagener C, et al.
Inflamm Bowel Dis . 2018 Oct; 25(2):294-305. PMID: 30295747
Background: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) displays multiple activities, among which pathogen binding and angiogenesis are particularly prominent. These same functions are also exerted by Toll- and NOD-like...
8.
Wicklein D, Otto B, Suling A, Elies E, Luers G, Lange T, et al.
Sci Rep . 2018 Aug; 8(1):11893. PMID: 30089785
We investigated the functional role of CEACAM1 in a spontaneous metastasis xenograft model of human melanoma in scid mice using BRAF wildtype MeWo cells with and without RNAi mediated knockdown...
9.
Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, et al.
Oncotarget . 2016 Aug; 7(39):63730-63746. PMID: 27572314
We analyzed the molecular basis for carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-controlled inhibition of epithelial-mesenchymal transition (EMT) in a mouse model for mammary adenocarcinoma (WAP-T mice). We demonstrate that...
10.
Wagener C, Singer B
Exp Cell Res . 2015 Oct; 341(1):75-76. PMID: 26485641
Family members, friends and colleagues of Prof. Dr. Dr. h.c. Björn Öbrink were deeply saddened to learn of his sudden death on August 21, 2015. Björn was one of the...