Christoph Arkona
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Explore the profile of Christoph Arkona including associated specialties, affiliations and a list of published articles.
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20
Citations
160
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Recent Articles
1.
Wahl J, Ahsanullah , Zupan H, Gottschalk F, Nerlich A, Arkona C, et al.
Angew Chem Int Ed Engl
. 2024 Oct;
63(49):e202411006.
PMID: 39380558
Diazo peptides have been described earlier, however, due to their high reactivity have not been broadly used until today. Here, we report the preparation, properties, and applications of chemically stable...
2.
Aziz U, Saoud A, Bermudez M, Mieth M, Atef A, Rudolf T, et al.
Nat Commun
. 2024 May;
15(1):4323.
PMID: 38773122
No abstract available.
3.
Aziz U, Saoud A, Bermudez M, Mieth M, Atef A, Rudolf T, et al.
Nat Commun
. 2024 Apr;
15(1):3537.
PMID: 38670939
Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pneumoniae, the main cause for bacterial pneumonia. Liberation of PLY during infection leads to compromised immune system and cytolytic cell death....
4.
Wamser R, Zhang X, Kuropka B, Arkona C, Rademann J
Chemistry
. 2024 Jan;
30(17):e202303940.
PMID: 38246870
Protein-templated fragment ligation was established as a method for the rapid identification of high affinity ligands, and multicomponent reactions (MCR) such as the Ugi four-component reaction (Ugi 4CR) have been...
5.
Jia Y, Schroeder B, Pfeifer Y, Frohlich C, Deng L, Arkona C, et al.
J Med Chem
. 2023 Aug;
66(17):11761-11791.
PMID: 37585683
Carbapenem resistance mediated by metallo-β-lactamases (MBL) such as New Delhi metallo-β-lactamase-1 (NDM-1) has become a major factor threatening the efficacy of essential β-lactam antibiotics. Starting from hit fragment dipicolinic acid...
6.
Wamser R, Pach S, Arkona C, Baumgardt M, Aziz U, Hocke A, et al.
ChemMedChem
. 2023 Feb;
18(9):e202200635.
PMID: 36812048
SARS coronavirus main proteases (3CL proteases) have been validated as pharmacological targets for the treatment of coronavirus infections. Current inhibitors of SARS main protease, including the clinically admitted drug nirmatrelvir...
7.
Tiemann M, Nawrotzky E, Schmieder P, Wehrhan L, Bergemann S, Martos V, et al.
Chemistry
. 2022 Jul;
28(57):e202201282.
PMID: 35781901
Discovery of protein-binding fragments for precisely defined binding sites is an unmet challenge to date. Herein, formylglycine is investigated as a molecular probe for the sensitive detection of fragments binding...
8.
Schroeder B, Demirel P, Fischer C, Masri E, Kallis S, Redl L, et al.
ACS Med Chem Lett
. 2021 Dec;
12(12):1955-1961.
PMID: 34917260
Viral proteases have been established as drug targets in several viral diseases including human immunodeficiency virus and hepatitis C virus infections due to the essential role of these enzymes in...
9.
Tauber C, Wamser R, Arkona C, Tugend M, Aziz U, Pach S, et al.
Angew Chem Int Ed Engl
. 2021 Mar;
60(24):13294-13301.
PMID: 33749121
The generation of bioactive molecules from inactive precursors is a crucial step in the chemical evolution of life, however, mechanistic insights into this aspect of abiogenesis are scarce. Here, we...
10.
Jaegle M, Wong E, Tauber C, Nawrotzky E, Arkona C, Rademann J
Angew Chem Weinheim Bergstr Ger
. 2020 Apr;
129(26):7464-7485.
PMID: 32313319
No abstract available.