Christoph A Merten
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Explore the profile of Christoph A Merten including associated specialties, affiliations and a list of published articles.
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48
Citations
1289
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Recent Articles
1.
Hu H, Zhou F, Ma X, Brokstad K, Kolmar L, Girardot C, et al.
PNAS Nexus
. 2025 Jan;
4(1):pgaf006.
PMID: 39867668
Here, we present Link-Seq, a highly efficient droplet microfluidic method for combined sequencing of antibody-encoding genes and the transcriptome of individual B cells at large scale. The method is based...
2.
Autour A, Merten C
Proc Natl Acad Sci U S A
. 2024 Sep;
121(37):e2405342121.
PMID: 39240970
Droplet microfluidics has become a very powerful tool in high-throughput screening, including antibody discovery. Screens are usually carried out by physically sorting droplets hosting cells of the desired phenotype, breaking...
3.
4.
Johansson S, Dulermo T, Jann C, Smith J, Pryszlak A, Pignede G, et al.
Lab Chip
. 2023 Jul;
23(16):3704-3715.
PMID: 37483015
Key to our ability to increase recombinant protein production through secretion is a better understanding of the pathways that interact to translate, process and export mature proteins to the surrounding...
5.
Panwar J, Utharala R, Fennelly L, Frenzel D, Merten C
Cell Rep Methods
. 2023 Jun;
3(5):100478.
PMID: 37323570
Fluorescence-activated droplet sorting (FADS) is a widely used microfluidic technique for high-throughput screening. However, it requires highly trained specialists to determine optimal sorting parameters, and this results in a large...
6.
Panwar J, Merten C
Lab Chip
. 2023 May;
23(11):2514-2520.
PMID: 37199565
Crosstalk between fluorescent biomarkers significantly limits the resolution of multispectral fluorescence analysis in real-time droplet-microfluidics applications. The crosstalk is a result of overlapping emission and excitation spectra of different fluorophores...
7.
Panwar J, Autour A, Merten C
Nat Protoc
. 2023 Jan;
18(4):1090-1136.
PMID: 36707723
Droplet microfluidics has revolutionized quantitative high-throughput bioassays and screening, especially in the field of single-cell analysis where applications include cell characterization, antibody discovery and directed evolution. However, droplet microfluidic platforms...
8.
Heijo H, Merten C, Hara Y
Dev Growth Differ
. 2022 Oct;
64(9):501-507.
PMID: 36308491
Size of the nucleus, a membrane-bound organelle for DNA replication and transcription in eukaryotic cells, varies to adapt nuclear functions to the surrounding environment. Nuclear size strongly correlates with cytoplasmic...
9.
Utharala R, Grab A, Vafaizadeh V, Peschke N, Ballinger M, Turei D, et al.
Nat Protoc
. 2022 Oct;
17(12):2920-2965.
PMID: 36261631
Droplet microfluidics is a powerful tool for a variety of biological applications including single-cell genetics, antibody discovery and directed evolution. All these applications make use of genetic libraries, illustrating the...
10.
Kolmar L, Autour A, Ma X, Vergier B, Eduati F, Merten C
Trends Cell Biol
. 2022 May;
32(11):947-961.
PMID: 35577671
Engineering and computational advances have opened many new avenues in cancer research, particularly when being exploited in interdisciplinary approaches. For example, the combination of microfluidics, novel sequencing technologies, and computational...