Christine Peinelt
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Explore the profile of Christine Peinelt including associated specialties, affiliations and a list of published articles.
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47
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1716
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Recent Articles
1.
Bochen F, Subedi S, La Manna F, Jarrin S, Papapostolou I, Kruithof-de Julio M, et al.
Mol Oncol
. 2025 Jan;
PMID: 39821469
Transient receptor potential melastatin-4 (TRPM4) ion channel expression is upregulated in prostate cancer (PCa), contributing to increased cell proliferation, migration, adhesion, epithelial-to-mesenchymal transition, cell cycle shift, and alterations of intracellular...
2.
Kappel S, Melek K, Ross-Kaschitza D, Hauert B, Gerber C, Lochner M, et al.
Front Pharmacol
. 2024 Mar;
15:1369513.
PMID: 38515848
Upon activation at low pH, TMEM206 conducts Cl ions across plasma and vesicular membranes. In a (patho)physiological context, TMEM206 was reported to contribute to acid-induced cell death in neurons, kidney...
3.
Preti B, Rougier J, Papapostolou I, Bochen F, Gerber C, Abriel H, et al.
Chimia (Aarau)
. 2023 Dec;
76(12):1039-1044.
PMID: 38069800
The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors...
4.
Tscherrig D, Bhardwaj R, Biner D, Dernic J, Ross-Kaschitza D, Peinelt C, et al.
Cell Calcium
. 2023 Nov;
117:102834.
PMID: 38006628
Many physiological functions, such as cell differentiation, proliferation, muscle contraction, neurotransmission and fertilisation, are regulated by changes of Ca levels. The major Ca store in cells is the endoplasmic reticulum...
5.
Papapostolou I, Bochen F, Peinelt C, Maldifassi M
Methods Protoc
. 2023 Oct;
6(5).
PMID: 37888026
Although 2D in vitro cancer cell cultures have been used for decades as a first line-of-research tool to investigate antitumoral drugs and treatments, their use presents many drawbacks, including the...
6.
Papapostolou I, Ross-Kaschitza D, Bochen F, Peinelt C, Maldifassi M
Cells
. 2023 Aug;
12(15).
PMID: 37566079
Nicotine in tobacco is known to induce tumor-promoting effects and cause chemotherapy resistance through the activation of nicotinic acetylcholine receptors (nAChRs). Many studies have associated the α5 nicotinic receptor subunit...
7.
Kappel S, Peinelt C
EMBO Mol Med
. 2022 Aug;
14(9):e16489.
PMID: 35969215
Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases of the human gastrointestinal (GI) tract that are characterized by perturbations in the intestinal immune responses. In their study,...
8.
Augustynek B, Gyimesi G, Dernic J, Sallinger M, Albano G, Klesse G, et al.
Cell Calcium
. 2022 Jul;
105:102616.
PMID: 35792401
In humans, there are three paralogs of the Orai Ca channel that form the core of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels...
9.
Stoklosa P, Kappel S, Peinelt C
Cells
. 2022 Jun;
11(11).
PMID: 35681487
Under physiological conditions, the widely expressed calcium-activated TRPM4 channel conducts sodium into cells. This sodium influx depolarizes the plasma membrane and reduces the driving force for calcium entry. The aberrant...
10.
Kappel S, Ross-Kaschitza D, Hauert B, Rother K, Peinelt C
Cell Calcium
. 2022 May;
104:102591.
PMID: 35500522
Altered expression of transient receptor potential channel melastatin 4 (TRPM4) contributes to several diseases, including cardiac conduction disorders, immune diseases, and cancer. Yet the underlying mechanisms of TRPM4 expression changes...