Christine Mayr
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Explore the profile of Christine Mayr including associated specialties, affiliations and a list of published articles.
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38
Citations
6719
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Recent Articles
1.
Boraas L, Hu M, Martino P, Thornton L, Vejnar C, Zhen G, et al.
Cell Rep
. 2025 Jan;
44(2):115237.
PMID: 39883578
The subcellular localization of mRNAs plays a pivotal role in biological processes, including cell migration. For instance, β-actin mRNA and its associated RNA-binding protein (RBP), ZBP1/IGF2BP1, are recruited to focal...
2.
Chen X, Fansler M, Janjos U, Ule J, Mayr C
Cell
. 2024 Aug;
187(18):5048-5063.e25.
PMID: 39106863
It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we report the fragile X-related protein 1 (FXR1) network, an mRNA-protein (mRNP) network present throughout the...
3.
Fansler M, Mitschka S, Mayr C
Nat Commun
. 2024 May;
15(1):4050.
PMID: 38744866
Although more than half of all genes generate transcripts that differ in 3'UTR length, current analysis pipelines only quantify the amount but not the length of mRNA transcripts. 3'UTR length...
4.
Horste E, Fansler M, Cai T, Chen X, Mitschka S, Zhen G, et al.
Mol Cell
. 2023 Dec;
83(24):4509-4523.e11.
PMID: 38134885
The cytoplasm is highly compartmentalized, but the extent and consequences of subcytoplasmic mRNA localization in non-polarized cells are largely unknown. We determined mRNA enrichment in TIS granules (TGs) and the...
5.
Chen X, Fansler M, Janjos U, Ule J, Mayr C
bioRxiv
. 2023 Nov;
PMID: 37961296
It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we report the FXR1 network, an mRNA-protein (mRNP) network present throughout the cytoplasm, formed by FXR1-mediated...
6.
Mayr C, Mittag T, Tang T, Wen W, Zhang H, Zhang H
Nat Cell Biol
. 2023 Mar;
25(4):512-514.
PMID: 36973422
No abstract available.
7.
Luo Y, Pratihar S, Horste E, Mitschka S, Mey A, Al-Hashimi H, et al.
bioRxiv
. 2023 Feb;
PMID: 36824771
The cytoplasm is compartmentalized into different translation environments. mRNAs use their 3'UTRs to localize to distinct cytoplasmic compartments, including TIS granules (TGs). Many transcription factors, including MYC, are translated in...
8.
Mitschka S, Mayr C
Nat Rev Mol Cell Biol
. 2022 Jul;
23(12):779-796.
PMID: 35798852
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate mRNA isoforms with alternative 3' untranslated regions (UTRs). The expression of alternative 3' UTR isoforms is highly cell type...
9.
Kwon B, Fansler M, Patel N, Lee J, Ma W, Mayr C
Nat Commun
. 2022 May;
13(1):2709.
PMID: 35581194
Multi-UTR genes are widely transcribed and express their alternative 3'UTR isoforms in a cell type-specific manner. As transcriptional enhancers regulate mRNA expression, we investigated if they also regulate 3'UTR isoform...
10.
Chen X, Mayr C
RNA
. 2021 Oct;
28(1):76-87.
PMID: 34706978
Most cellular processes are carried out by protein complexes, but it is still largely unknown how the subunits of lowly expressed complexes find each other in the crowded cellular environment....