Christina J van Lier
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Explore the profile of Christina J van Lier including associated specialties, affiliations and a list of published articles.
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12
Citations
265
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Recent Articles
1.
Tiner B, Sha J, Ponnusamy D, Baze W, Fitts E, Popov V, et al.
Clin Vaccine Immunol
. 2015 Oct;
22(12):1255-68.
PMID: 26446423
Earlier, we showed that the Δlpp ΔmsbB Δail triple mutant of Yersinia pestis CO92 with deleted genes encoding Braun lipoprotein (Lpp), an acyltransferase (MsbB), and the attachment invasion locus (Ail),...
2.
van Lier C, Tiner B, Chauhan S, Motin V, Fitts E, Huante M, et al.
Microb Pathog
. 2015 Feb;
80:27-38.
PMID: 25697665
We recently characterized the Δlpp Δpla double in-frame deletion mutant of Yersinia pestis CO92 molecularly, biologically, and immunologically. While Braun lipoprotein (Lpp) activates toll-like receptor-2 to initiate an inflammatory cascade,...
3.
Tiner B, Sha J, Kirtley M, Erova T, Popov V, Baze W, et al.
Infect Immun
. 2015 Jan;
83(4):1318-38.
PMID: 25605764
Previously, we showed that deletion of genes encoding Braun lipoprotein (Lpp) and MsbB attenuated Yersinia pestis CO92 in mouse and rat models of bubonic and pneumonic plague. While Lpp activates...
4.
Grim C, Kozlova E, Ponnusamy D, Fitts E, Sha J, Kirtley M, et al.
Appl Environ Microbiol
. 2014 May;
80(14):4162-83.
PMID: 24795370
The genomes of 10 Aeromonas isolates identified and designated Aeromonas hydrophila WI, Riv3, and NF1 to NF4; A. dhakensis SSU; A. jandaei Riv2; and A. caviae NM22 and NM33 were...
5.
van Lier C, Sha J, Kirtley M, Cao A, Tiner B, Erova T, et al.
Infect Immun
. 2014 Apr;
82(6):2485-503.
PMID: 24686064
Currently, there is no FDA-approved vaccine against Yersinia pestis, the causative agent of bubonic and pneumonic plague. Since both humoral immunity and cell-mediated immunity are essential in providing the host...
6.
Lawal A, Kirtley M, van Lier C, Erova T, Kozlova E, Sha J, et al.
Astrobiology
. 2013 Aug;
13(9):821-32.
PMID: 23988036
Previously, we reported that there was no enhancement in the virulence potential (as measured by cell culture infections) of the bacterial pathogen Yersinia pestis (YP) following modeled microgravity/clinorotation growth. We...
7.
Tao P, Mahalingam M, Kirtley M, van Lier C, Sha J, Yeager L, et al.
PLoS Pathog
. 2013 Jul;
9(7):e1003495.
PMID: 23853602
Pneumonic plague is a highly virulent infectious disease with 100% mortality rate, and its causative organism Yersinia pestis poses a serious threat for deliberate use as a bioterror agent. Currently,...
8.
Grim C, Kozlova E, Sha J, Fitts E, van Lier C, Kirtley M, et al.
mBio
. 2013 Apr;
4(2):e00064-13.
PMID: 23611906
Unlabelled: Aeromonas hydrophila has increasingly been implicated as a virulent and antibiotic-resistant etiologic agent in various human diseases. In a previously published case report, we described a subject with a...
9.
Sha J, Rosenzweig J, Kozlova E, Wang S, Erova T, Kirtley M, et al.
Microbiology (Reading)
. 2013 Mar;
159(Pt 6):1120-1135.
PMID: 23519162
Aeromonas hydrophila, a Gram-negative bacterium, is an emerging human pathogen equipped with both a type 3 and a type 6 secretion system (T6SS). In this study, we evaluated the roles...
10.
Sha J, Kirtley M, van Lier C, Wang S, Erova T, Kozlova E, et al.
Infect Immun
. 2013 Jan;
81(3):815-28.
PMID: 23275092
Braun (murein) lipoprotein (Lpp) and lipopolysaccharide (LPS) are major components of the outer membranes of Enterobacteriaceae family members that are capable of triggering inflammatory immune responses by activating Toll-like receptors...