Christina A Castellani
Overview
Explore the profile of Christina A Castellani including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
34
Citations
658
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Lai M, Kim K, Zheng Y, Castellani C, Ratliff S, Wang M, et al.
medRxiv
. 2024 Dec;
PMID: 39677472
The relationship between mitochondrial DNA (mtDNA) heteroplasmy and nuclear DNA (nDNA) methylation (CpGs) remains to be studied. We conducted an epigenome-wide association analysis of heteroplasmy burden scores across 10,986 participants...
2.
Nguyen J, Win P, Nagano T, Shin E, Newcomb C, Arking D, et al.
bioRxiv
. 2024 Feb;
PMID: 38352513
Mitochondrial DNA copy number (mtDNA-CN) is associated with several age-related chronic diseases and is a predictor of all-cause mortality. Here, we examine site-specific differential nuclear DNA (nDNA) methylation and differential...
3.
Win P, Nyugen J, Morin A, Newcomb C, Singh S, Gomaa N, et al.
BMC Res Notes
. 2024 Jan;
17(1):21.
PMID: 38212867
Objective: Mitochondrial dysfunction and nuclear epigenetic alterations, two hallmarks of aging, are associated with aberrant development and complex disease risk. Here, we report a method for the simultaneous assessment of...
4.
Nguyen J, Le Q, Win P, Hill K, Singh S, Castellani C
Epigenomics
. 2023 Nov;
15(21):1121-1136.
PMID: 38031736
Bidirectional communication between the mitochondria and the nucleus is required for several physiological processes, and the nuclear epigenome is a key mediator of this relationship. ncRNAs are an emerging area...
5.
Win P, Singh S, Castellani C
Twin Res Hum Genet
. 2023 Sep;
:1-10.
PMID: 37655526
Schizophrenia (SZ) is a severe, complex, and common mental disorder with high heritability (80%), an adult age of onset, and high discordance (∼50%) in monozygotic twins (MZ). Extensive studies on...
6.
Morin A, Win P, Lin A, Castellani C
Front Endocrinol (Lausanne)
. 2022 Nov;
13:1059085.
PMID: 36419771
Bidirectional crosstalk between the nuclear and mitochondrial genomes is essential for proper cell functioning. Mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy influence mitochondrial function, which can influence the nuclear genome...
7.
Kirk E, Castellani C, Doherty T, Rice C, Singh S
Physiol Genomics
. 2022 Jun;
54(8):305-315.
PMID: 35723223
Skeletal muscle is adaptable to a direct stimulus of exercise-induced muscle damage (EIMD). Local muscle gene networks and systemic circulatory factors respond to EIMD within days, mediating anti-inflammation and cellular...
8.
Patil N, Feng B, Su Z, Castellani C, Chakrabarti S
Sci Rep
. 2021 Dec;
11(1):23766.
PMID: 34887449
Chronic diabetic complications affect multiple organs causing widespread organ damage. Although there are some commonalities, the phenotype of such changes show tissue specific variation. Given this, we examined whether differences...
9.
Wang P, Castellani C, Yao J, Huan T, Bielak L, Zhao W, et al.
Hum Mol Genet
. 2021 Aug;
31(2):309-319.
PMID: 34415308
We conducted cohort- and race-specific epigenome-wide association analyses of mitochondrial deoxyribonucleic acid (mtDNA) copy number (mtDNA CN) measured in whole blood from participants of African and European origins in five...
10.
Yang S, Castellani C, Longchamps R, Pillalamarri V, ORourke B, Guallar E, et al.
Genome Res
. 2021 Jan;
31(3):349-358.
PMID: 33441415
Mitochondrial DNA copy number (mtDNA-CN) is a proxy for mitochondrial function and is associated with aging-related diseases. However, it is unclear how mtDNA-CN measured in blood can reflect diseases that...