Christie A M Peebles
Overview
Explore the profile of Christie A M Peebles including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
24
Citations
278
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0
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Recent Articles
1.
Morey K, Peebles C
Front Plant Sci
. 2022 Aug;
13:937095.
PMID: 35991443
While plants are an abundant source of valuable natural products, it is often challenging to produce those products for commercial application. Often organic synthesis is too expensive for a viable...
2.
Werner A, Broeckling C, Prasad A, Peebles C
Plant J
. 2019 Mar;
99(2):379-388.
PMID: 30889309
Cyanobacteria are a model photoautotroph and a chassis for the sustainable production of fuels and chemicals. Knowledge of photoautotrophic metabolism in the natural environment of day/night cycles is lacking, yet...
3.
Sun J, Zhao L, Shao Z, Shanks J, Peebles C
Biotechnol Bioeng
. 2017 Nov;
115(3):673-683.
PMID: 29105731
The monoterpene indole alkaloids vindoline and catharanthine, which are exclusively synthesized in the medicinal plant Catharanthus roseus, are the two important precursors for the production of pharmaceutically important anti-cancer medicines...
4.
Sun J, Ma L, San K, Peebles C
Biotechnol Prog
. 2016 Nov;
33(1):66-69.
PMID: 27813337
Hairy root cultures generated using Agrobacterium rhizogenes are an extensively investigated system for the overproduction of various secondary metabolite based pharmaceuticals and chemicals. This study demonstrated a transgenic Catharanthus roseus...
5.
Albers S, Peebles C
Biotechnol Prog
. 2016 Nov;
33(1):45-53.
PMID: 27798958
Cyanobacteria are enticing microbial factories, but little is understood how their gene control elements respond to the periodic availability to light. This research tested the capability of P to control...
6.
Sun J, Manmathan H, Sun C, Peebles C
BMC Plant Biol
. 2016 May;
16(1):108.
PMID: 27154243
Background: Clinically important anti-cancer drugs vinblastine and vincristine are solely synthesized by the terpenoid indole alkaloid (TIA) pathway in Catharanthus roseus. Anthranilate synthase (AS) is a rate-limiting enzyme in the...
7.
Albers S, Gallegos V, Peebles C
J Biotechnol
. 2015 Oct;
216:36-46.
PMID: 26450561
Cyanobacteria show promise as photosynthetic microbial factories capable of harnessing sunlight and CO2 to produce valuable end products, but few genetic control tools have been characterized and utilized in these...
8.
Sun J, Peebles C
Protoplasma
. 2015 Sep;
253(5):1255-64.
PMID: 26351111
Catharanthus roseus produces many pharmaceutically important terpenoid indole alkaloids (TIAs) such as vinblastine, vincristine, ajmalicine, and serpentine. Past metabolic engineering efforts have pointed to the tight regulation of the TIA...
9.
Cheah Y, Albers S, Peebles C
Biotechnol Prog
. 2012 Nov;
29(1):23-30.
PMID: 23124993
The cyanobacterium Synechocystis sp. PCC 6803 is a photosynthetic organism capable of efficient harnessing of solar energy while capturing CO(2) from the environment. Methods to genetically alter its genomic DNA...
10.
Chung I, Kim E, Li M, Peebles C, Jung W, Song H, et al.
Biotechnol Prog
. 2011 Jun;
27(4):937-43.
PMID: 21674816
The leaves of Catharanthus roseus (L.) G. Don. are a valuable source of the terpenoid indole alkaloid (TIA) anticancer drugs, vinblastine and vincristine. In particular, the precursor molecules vindoline and...