Christiane Wirbelauer
Overview
Explore the profile of Christiane Wirbelauer including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
2634
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Recent Articles
1.
Iurlaro M, Masoni F, Flyamer I, Wirbelauer C, Iskar M, Burger L, et al.
Nat Genet
. 2024 Nov;
56(11):2574-2575.
PMID: 39487354
No abstract available.
2.
Iurlaro M, Masoni F, Flyamer I, Wirbelauer C, Iskar M, Burger L, et al.
Nat Genet
. 2024 May;
56(6):1203-1212.
PMID: 38816647
Catalytic activity of the imitation switch (ISWI) family of remodelers is critical for nucleosomal organization and DNA binding of certain transcription factors, including the insulator protein CTCF. Here we define...
3.
Kaluscha S, Domcke S, Wirbelauer C, Stadler M, Durdu S, Burger L, et al.
Nat Genet
. 2022 Dec;
54(12):1895-1906.
PMID: 36471082
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats in mammalian genomes. To what extent this entails direct inhibition of transcription factor (TF) binding versus indirect inhibition via...
4.
Hartl D, Krebs A, Grand R, Baubec T, Isbel L, Wirbelauer C, et al.
Genome Res
. 2019 Feb;
29(4):554-563.
PMID: 30709850
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is unknown...
5.
Baubec T, Colombo D, Wirbelauer C, Schmidt J, Burger L, Krebs A, et al.
Nature
. 2015 Jan;
520(7546):243-7.
PMID: 25607372
DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases...
6.
Tiwari V, Burger L, Nikoletopoulou V, Deogracias R, Thakurela S, Wirbelauer C, et al.
Proc Natl Acad Sci U S A
. 2012 Apr;
109(16):E934-43.
PMID: 22474351
Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets and function in postmitotic cells remain poorly understood. Here we show that a switch in the expression...
7.
Tiwari V, Stadler M, Wirbelauer C, Paro R, Schubeler D, Beisel C
Nat Genet
. 2011 Dec;
44(1):94-100.
PMID: 22179133
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH(2)-terminal kinase (JNK) pathway exemplifies one subgroup of the mitogen-activated protein (MAP) kinases, which, besides having established functions in stress response,...
8.
Stadler M, Murr R, Burger L, Ivanek R, Lienert F, Scholer A, et al.
Nature
. 2011 Dec;
480(7378):490-5.
PMID: 22170606
Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet the rules that govern methylation patterns remain largely elusive. To gain insights into this process, we generated base-pair-resolution...
9.
Lienert F, Wirbelauer C, Som I, Dean A, Mohn F, Schubeler D
Nat Genet
. 2011 Oct;
43(11):1091-7.
PMID: 21964573
Cytosine methylation is a repressive, epigenetically propagated DNA modification. Although patterns of DNA methylation seem tightly regulated in mammals, it is unclear how these are specified and to what extent...
10.
Bell O, Conrad T, Kind J, Wirbelauer C, Akhtar A, Schubeler D
Mol Cell Biol
. 2008 Mar;
28(10):3401-9.
PMID: 18347056
In Drosophila melanogaster, dosage compensation relies on the targeting of the male-specific lethal (MSL) complex to hundreds of sites along the male X chromosome. Transcription-coupled methylation of histone H3 lysine...