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Christiane Scherer

Explore the profile of Christiane Scherer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 87
Followers 0
Related Specialties
Chemistry
Microbiology
Pharmacology
Top 10 Co-Authors
Rolf W Hartmann
Ursula Muller-Vieira
Klaus Biemel
Sandrine Marchais-Oberwinkler
Martina Streiber
Martin Frotscher
Iris Antes
Olaf Kaup
Marc Diederich
Marieke Voets
Published In
J Med Chem
J Clin Microbiol
Apoptosis
Artif Intell Med
J Pharm Sci
Affiliations
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Recent Articles
1.
Integrating federated learning for improved counterfactual explanations in clinical decision support systems for sepsis therapy
Dusing C, Cimiano P, Rehberg S, Scherer C, Kaup O, Koster C, et al.
Artif Intell Med . 2024 Sep; 157:102982. PMID: 39277983
In recent years, we have witnessed both artificial intelligence obtaining remarkable results in clinical decision support systems (CDSSs) and explainable artificial intelligence (XAI) improving the interpretability of these models. In...
2.
[Diagnostic stewardship in outpatient and hospital medicine with focus on microbiological urinary and bloodstream diagnostics]
Bornemann R, Hartmann J, Kaup O, Probst-Kepper M, Scherer C
Dtsch Med Wochenschr . 2024 Feb; 149(5):231-239. PMID: 38350608
Targeted infection diagnosis supports decision-making in the rational use of antibiotics usually encompassed as Antibiotic Stewardship (ABS). Similar to ABS, the term "Diagnostic Stewardship" (DGS) is suggested, whereas DGS includes,...
3.
Multiple Occurrences of a 168-Nucleotide Deletion in SARS-CoV-2 ORF8, Unnoticed by Standard Amplicon Sequencing and Variant Calling Pipelines
Brandt D, Simunovic M, Busche T, Haak M, Belmann P, Junemann S, et al.
Viruses . 2021 Sep; 13(9). PMID: 34578452
Genomic surveillance of the SARS-CoV-2 pandemic is crucial and mainly achieved by amplicon sequencing protocols. Overlapping tiled-amplicons are generated to establish contiguous SARS-CoV-2 genome sequences, which enable the precise resolution...
4.
Synthesis and selective anticancer activity of organochalcogen based redox catalysts
Doering M, Ba L, Lilienthal N, Nicco C, Scherer C, Abbas M, et al.
J Med Chem . 2010 Sep; 53(19):6954-63. PMID: 20836556
Many tumor cells exhibit a disturbed intracellular redox state resulting in higher levels of reactive oxygen species (ROS). As these contribute to tumor initiation and sustenance, catalytic redox agents combining...
5.
Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4)
Cerella C, Scherer C, Cristofanon S, Henry E, Anwar A, Busch C, et al.
Apoptosis . 2009 Mar; 14(5):641-54. PMID: 19266285
Naturally occurring organic sulfur compounds (OSCs), such as linear allylsulfides from Allium species, are attracting attention in cancer research, since several OSCs were shown to act beneficially both in chemoprevention...
6.
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent...
Frotscher M, Ziegler E, Marchais-Oberwinkler S, Kruchten P, Neugebauer A, Fetzer L, et al.
J Med Chem . 2008 Mar; 51(7):2158-69. PMID: 18324762
Human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the reduction of the weak estrogen estrone (E1) to the highly potent estradiol (E2). This reaction takes place in the target cell where...
7.
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis
Voets M, Antes I, Scherer C, Muller-Vieira U, Biemel K, Marchais-Oberwinkler S, et al.
J Med Chem . 2006 Mar; 49(7):2222-31. PMID: 16570918
In this study, the synthesis and biological evaluation of heteroaryl-substituted dihydronaphthalenes and indenes (1-16) is described. The compounds were tested for activity by use of human CYP11B2 expressed in fission...
8.
Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids
Salem O, Frotscher M, Scherer C, Neugebauer A, Biemel K, Streiber M, et al.
J Med Chem . 2006 Jan; 49(2):748-59. PMID: 16420060
Novel substituted benzoyl benzoic acids and phenylacetic acids 1-14 have been synthesized and evaluated for inhibition of rat and human steroid 5alpha-reductase isozymes 1 and 2. The compounds turned out...
9.
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis
Voets M, Antes I, Scherer C, Muller-Vieira U, Biemel K, Barassin C, et al.
J Med Chem . 2005 Oct; 48(21):6632-42. PMID: 16220979
Recently we proposed inhibition of aldosterone synthase (CYP11B2) as a novel strategy for the treatment of congestive heart failure and myocardial fibrosis. In this study the synthesis and biological evaluation...
10.
Methyl esters of N-(dicyclohexyl)acetyl-piperidine-4-(benzylidene-4-carboxylic acids) as drugs and prodrugs: a new strategy for dual inhibition of 5 alpha-reductase type 1 and type 2
Streiber M, Picard F, Scherer C, Seidel S, Hartmann R
J Pharm Sci . 2005 Jan; 94(3):473-80. PMID: 15627259
Steroid 5alpha-reductase (5alphaR) inhibitory potency of three N-(dicyclohexyl)acetyl-piperidine-4-(benzylidene-4-carboxylic acids) and their corresponding methyl esters was monitored for type 2 isoenzyme in a benign prostatic hyperplasia cell free preparation and for...