Christian S Diercks
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Explore the profile of Christian S Diercks including associated specialties, affiliations and a list of published articles.
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30
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1074
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Recent Articles
1.
Diercks C, Sondermann P, Rong C, Dik D, Gillis T, Ban Y, et al.
bioRxiv
. 2024 Aug;
PMID: 39211285
Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can dramatically accelerate the evolution of new or enhanced protein functions. We describe an...
2.
Pigula M, Lai Y, Koh M, Diercks C, Rogers T, Dik D, et al.
Nat Commun
. 2024 Aug;
15(1):6766.
PMID: 39117651
Live vaccines are ideal for inducing immunity but suffer from the need to attenuate their pathogenicity or replication to preclude the possibility of escape. Unnatural amino acids (UAAs) provide a...
3.
Diercks C, Dik D, Schultz P
Chem
. 2023 Aug;
7(11):2883-2895.
PMID: 37621702
The maturation of chemical synthesis during the 20 century has elevated the discipline from a largely empirical into a rational science. This ability to purposefully craft matter at the molecular...
4.
Ji Z, Kozuch J, Mathews I, Diercks C, Shamsudin Y, Schulz M, et al.
J Am Chem Soc
. 2022 Nov;
144(45):20947-20954.
PMID: 36324090
The widespread design of covalent drugs has focused on crafting reactive groups of proper electrophilicity and positioning toward targeted amino-acid nucleophiles. We found that environmental electric fields projected onto a...
5.
Andreo J, Ettlinger R, Zaremba O, Pena Q, Lachelt U, Fernandez de Luis R, et al.
J Am Chem Soc
. 2022 Apr;
144(17):7531-7550.
PMID: 35389641
The chemistry of metal-organic and covalent organic frameworks (MOFs and COFs) is perhaps the most diverse and inclusive among the chemical sciences, and yet it can be radically expanded by...
6.
Ji Z, Freund R, Diercks C, Hirschle P, Yaghi O, Wuttke S
Adv Mater
. 2021 Sep;
33(42):e2103808.
PMID: 34499785
Building chemical structures of complexity and functionality approaching the level of biological systems is an ongoing challenge. A general synthetic strategy is proposed by which progressive levels of complexity are...
7.
Freund R, Zaremba O, Arnauts G, Ameloot R, Skorupskii G, Dinca M, et al.
Angew Chem Int Ed Engl
. 2021 May;
60(45):23975-24001.
PMID: 33989445
The amalgamation of different disciplines is at the heart of reticular chemistry and has broadened the boundaries of chemistry by opening up an infinite space of chemical composition, structure, and...
8.
Freund R, Canossa S, Cohen S, Yan W, Deng H, Guillerm V, et al.
Angew Chem Int Ed Engl
. 2021 Mar;
60(45):23946-23974.
PMID: 33783111
At its core, reticular chemistry has translated the precision and expertise of organic and inorganic synthesis to the solid state. While initial excitement over metal-organic frameworks (MOFs) and covalent organic...
9.
Diercks C, Kalmutzki M, Yaghi O
Molecules
. 2020 Sep;
22(9).
PMID: 32961648
The synthesis of organic molecules has at its core, purity, definitiveness of structure, and the ability to access specific atoms through chemical reactions. When considering extended organic structures, covalent organic...
10.
Guo L, Jia S, Diercks C, Yang X, Alshmimri S, Yaghi O
Angew Chem Int Ed Engl
. 2019 Nov;
59(5):2023-2027.
PMID: 31705565
Three new post-synthetic modification reactions, namely amidation, esterification, and thioesterification, were demonstrated on a novel highly crystalline two-dimensional covalent organic framework (COF), COF-616, bearing pre-installed carboxyl groups. The strategy can...