Christian R A Regenbrecht
Overview
Explore the profile of Christian R A Regenbrecht including associated specialties, affiliations and a list of published articles.
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22
Citations
554
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Recent Articles
1.
Muller D, Loskutov J, Kuffer S, Marx A, Regenbrecht C, Strobel P, et al.
Cancers (Basel)
. 2024 Aug;
16(15).
PMID: 39123489
Cell culture model systems are fundamental tools for studying cancer biology and identifying therapeutic vulnerabilities in a controlled environment. TET cells are notoriously difficult to culture, with only a few...
2.
Roohani S, Loskutov J, Heufelder J, Ehret F, Wedeken L, Regenbrecht M, et al.
BMC Cancer
. 2023 Jun;
23(1):577.
PMID: 37349697
Background: Despite their heterogeneity, the current standard preoperative radiotherapy regimen for localized high-grade soft tissue sarcoma (STS) follows a one fits all approach for all STS subtypes. Sarcoma patient-derived three-dimensional...
3.
Pfohl U, Loskutov J, Bashir S, Kuhn R, Herter P, Templin M, et al.
Cancers (Basel)
. 2022 Jul;
14(13).
PMID: 35805024
In colorectal cancer (CRC), mutations of genes associated with the TGF-β/BMP signaling pathway, particularly affecting , are known to correlate with decreased overall survival and it is assumed that this...
4.
Regan J, Schumacher D, Staudte S, Steffen A, Lesche R, Toedling J, et al.
iScience
. 2022 Jun;
25(7):104498.
PMID: 35720265
Recent evidence demonstrates that colon cancer stem cells (CSCs) can generate neurons that synapse with tumor innervating fibers required for tumorigenesis and disease progression. Greater understanding of the mechanisms that...
5.
Sankarasubramanian S, Pfohl U, Regenbrecht C, Reinhard C, Wedeken L
Front Cell Dev Biol
. 2021 Nov;
9:760705.
PMID: 34805167
Pancreatic cancer is one of the deadliest cancers and remains a major unsolved health problem. While pancreatic ductal adenocarcinoma (PDAC) is associated with driver mutations in only four major genes...
6.
Regan J, Schumacher D, Staudte S, Steffen A, Lesche R, Toedling J, et al.
iScience
. 2021 Jun;
24(6):102618.
PMID: 34142064
Recent data suggest that therapy-resistant quiescent cancer stem cells (qCSCs) are the source of relapse in colon cancer. Here, using colon cancer patient-derived organoids and xenografts, we identify rare long-term...
7.
Pfohl U, Pflaume A, Regenbrecht M, Finkler S, Graf Adelmann Q, Reinhard C, et al.
Cells
. 2021 Apr;
10(4).
PMID: 33920536
Cancer is a multifactorial disease with increasing incidence. There are more than 100 different cancer types, defined by location, cell of origin, and genomic alterations that influence oncogenesis and therapeutic...
8.
Thole T, Toedling J, Sprussel A, Pfeil S, Savelyeva L, Capper D, et al.
Int J Cancer
. 2019 Jul;
146(4):1031-1041.
PMID: 31304977
Accurate modeling of intratumor heterogeneity presents a bottleneck against drug testing. Flexibility in a preclinical platform is also desirable to support assessment of different endpoints. We established the model system,...
9.
Schumacher D, Andrieux G, Boehnke K, Keil M, Silvestri A, Silvestrov M, et al.
PLoS Genet
. 2019 Mar;
15(3):e1008076.
PMID: 30925167
Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of targeted therapies under conditions capturing in vitro the...
10.
Gambara G, Gaebler M, Keilholz U, Regenbrecht C, Silvestri A
Front Pharmacol
. 2018 Mar;
9:77.
PMID: 29491834
Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of intra-tumor heterogeneity (ITH) for cancer progression. The different...