Christian P R Hackenberger
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Explore the profile of Christian P R Hackenberger including associated specialties, affiliations and a list of published articles.
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Articles
117
Citations
1477
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Recent Articles
1.
Able M, Kasper M, Vick B, Schwach J, Gao X, Schmitt S, et al.
Leukemia
. 2025 Jan;
39(3):632-642.
PMID: 39870768
Refractory disease and relapse are major challenges in acute myeloid leukemia (AML) therapy attributed to survival of leukemic stem cells (LSC). To target LSCs, antibody-drug conjugates (ADCs) provide an elegant...
2.
Kocak A, Homer A, Feida A, Telschow F, Lopez J, Baydaroglu C, et al.
Chem Commun (Camb)
. 2024 Apr;
60(36):4785-4788.
PMID: 38602157
We show that covalent labelling of sialic acids on live cell surfaces or mucin increases the fluorescence of the fluorescence molecular rotors (FMRs) CCVJ, Cy3 and thioazole orange, enabling wash-free...
3.
Galashov A, Kazakova E, Stieger C, Hackenberger C, Seitz O
Chem Sci
. 2024 Jan;
15(4):1297-1305.
PMID: 38274058
The study of mucin function requires access to highly -glycosylated peptides with multiple tandem repeats. Solid-phase synthesis would be a suitable method, however, the central problem in the synthesis of...
4.
Arafiles J, Franke J, Franz L, Gomez-Gonzalez J, Kemnitz-Hassanin K, Hackenberger C
J Am Chem Soc
. 2023 Oct;
PMID: 37906525
The delivery of functional proteins remains a major challenge in advancing biological and pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective strategy for the intracellular delivery of...
5.
Schmitt S, Machui P, Mai I, Herterich S, Wunder S, Cyprys P, et al.
Mol Cancer Ther
. 2023 Oct;
23(2):199-211.
PMID: 37828728
Topoisomerase I (TOP1) Inhibitors constitute an emerging payload class to engineer antibody-drug conjugates (ADC) as next-generation biopharmaceutical for cancer treatment. Existing ADCs are using camptothecin payloads with lower potency and...
6.
Lopez J, Dornan G, Boback N, Neuenschwander M, Oder A, Kemnitz-Hassanin K, et al.
Chembiochem
. 2023 Sep;
24(24):e202300555.
PMID: 37769151
Uridine diphosphate N-acetylglucosamine 2-epimerase (GNE) is a key enzyme in the sialic acid biosynthesis pathway. Sialic acids are primarily terminal carbohydrates on glycans and play fundamental roles in health and...
7.
Saha A, Mandal S, Arafiles J, Gomez-Gonzalez J, Hackenberger C, Brik A
Angew Chem Int Ed Engl
. 2023 Jul;
62(33):e202307870.
PMID: 37439000
No abstract available.
8.
Lopez J, Schmieder P, Kemnitz-Hassanin K, Asikoglu H, Celik A, Stieger C, et al.
Chem Sci
. 2023 Apr;
14(13):3482-3492.
PMID: 37006695
Sialic acids are part of the outermost component of the glycocalyx of all vertebrates; as such, they are fundamental markers in physiological and pathological processes. In this study, we introduce...
9.
Munasinghe D, Kasper M, Jasinski R, Kula K, Palusiak M, Celeda M, et al.
Chemistry
. 2023 Mar;
29(33):e202300806.
PMID: 36988029
By exploiting the unique reactivity of ethynyl-phosphonites we obtain novel P(V)-containing five-membered heterocycles via (3+2)-cyclization reactions with aldehydes or cycloaliphatic thioketones in satisfactory to excellent yields. Whereas reactions with thioketones...
10.
Hagenhaus V, Lopez J, Rosenstengel R, Neu C, Hackenberger C, Celik A, et al.
Biomolecules
. 2023 Mar;
13(3).
PMID: 36979358
Mutations in the gene coding for the bi-functional UDP--acetylglucosamine 2-epimerase/-acetylmannosamine kinase (GNE), the key enzyme of the sialic acid biosynthesis, are responsible for autosomal-recessive GNE myopathy (GNEM). GNEM is an...