Christian Markert
Overview
Explore the profile of Christian Markert including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
111
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Loesche C, Picard D, Van Hoorick B, Schuhmann I, Jager P, Klein K, et al.
Clin Transl Sci
. 2024 Feb;
17(2):e13724.
PMID: 38407540
LYS006 is a novel, highly potent and selective, new-generation leukotriene A4 hydrolase (LTA4H) inhibitor in clinical development for the treatment of neutrophil-driven inflammatory diseases. We describe the complex pharmacokinetic to...
2.
Thoma G, Markert C, Lueoend R, Miltz W, Spanka C, Bollbuck B, et al.
J Med Chem
. 2023 Nov;
66(23):16410-16425.
PMID: 38015154
The discovery of chiral amino alcohols derived from our previously disclosed clinical LTA4H inhibitor is described. In a biochemical assay, their optical antipodes showed similar potencies, which could be rationalized...
3.
Markert C, Thoma G, Srinivas H, Bollbuck B, Luond R, Miltz W, et al.
J Med Chem
. 2021 Feb;
64(4):1889-1903.
PMID: 33592148
The cytosolic metalloenzyme leukotriene A hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B (LTB). Preclinical studies have validated this enzyme as an attractive...
4.
Numao S, Hasler F, Laguerre C, Srinivas H, Wack N, Jager P, et al.
Sci Rep
. 2017 Oct;
7(1):13591.
PMID: 29051536
Leukotriene A4 Hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that comprises both epoxide hydrolase and aminopeptidase activity, exerted by two overlapping catalytic sites. The epoxide hydrolase function of the enzyme...
5.
Wagner J, Markert C, Fischer B, Muller L
Phys Rev Lett
. 2014 Aug;
110(4):048301.
PMID: 25166207
Rodlike hematite particles in suspension align perpendicular to an external magnetic field due to a negative anisotropy of their magnetic susceptibility Δχ. The diffusion tensor consists of two principal constants...
6.
Ebner C, Muller C, Markert C, Pfaltz A
J Am Chem Soc
. 2011 Mar;
133(13):4710-3.
PMID: 21401128
The enantioselectivity of a chiral catalyst can be determined from its racemic form by mass spectrometric screening of a nonequal mixture of two mass-labeled quasienantiomeric substrates. The presented method opens...
7.
Arezki B, Schwarz G, Bodenthin Y, Luetzenkirchen-Hecht D, Markert C, Wagner R, et al.
Chemphyschem
. 2011 Jan;
12(2):405-10.
PMID: 21275032
X-ray absorption near the iron K edge (XANES) was used to investigate the characteristics of temperature-induced low-spin-to-high-spin change (SC) in metallo-supramolecular polyelectrolyte amphiphile complexes (PAC) containing FeN(6) octahedra attached to...
8.
Muller C, Markert C, Teichert A, Pfaltz A
Chem Commun (Camb)
. 2009 Mar;
(13):1607-18.
PMID: 19294243
The use of quasi-enantiomeric substrates and ESI-MS as an analytical tool has made it possible to determine the intrinsic enantioselectivity of chiral catalysts by monitoring catalytic intermediates. In this way,...
9.
Markert C, Rosel P, Pfaltz A
J Am Chem Soc
. 2008 Feb;
130(11):3234-5.
PMID: 18284236
No abstract available.
10.
Markert C, Neuburger M, Kulicke K, Meuwly M, Pfaltz A
Angew Chem Int Ed Engl
. 2007 Jun;
46(31):5892-5.
PMID: 17568469
No abstract available.