Christian Hilty
Overview
Explore the profile of Christian Hilty including associated specialties, affiliations and a list of published articles.
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Articles
96
Citations
1515
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Recent Articles
1.
Pham P, Biswas O, Hilty C
J Am Chem Soc
. 2024 Dec;
146(50):34274-34278.
PMID: 39652060
A medium containing reverse micelles supports non-hydrogenative parahydrogen induced polarization (nhPHIP) in the organic phase while solubilizing a protein in the aqueous phase. Strongly enhanced NMR signals from iridium hydride...
2.
Pradhan N, Hilty C
J Am Chem Soc
. 2024 Sep;
146(36):24754-24758.
PMID: 39225120
Hyperpolarization derived from water protons enhances the NMR signal of N nuclei in a small molecule, enabling the sensitive detection of a protein-ligand interaction. The water hyperpolarized by dissolution dynamic...
3.
Qi C, Mankinen O, Telkki V, Hilty C
J Am Chem Soc
. 2024 Feb;
146(8):5063-5066.
PMID: 38373110
Protein-ligand interactions can be detected by observing changes in the transverse relaxation rates of the ligand upon binding. The ultrafast NMR technique, which correlates the chemical shift with the transverse...
4.
Zhang Z, Gautam A, Lim S, Hilty C
J Chem Educ
. 2024 Feb;
100(10):4109-4113.
PMID: 38357475
We describe an update to an experiment demonstrating low-field NMR spectroscopy in the undergraduate physical chemistry laboratory. A Python-based data processing and analysis protocol is developed for this experiment. The...
5.
Pham P, Hilty C
Anal Chem
. 2023 Nov;
95(46):16911-16917.
PMID: 37931028
Nuclear magnetic resonance (NMR) relaxometry at a low magnetic field, in the milli-Tesla range or less, is enabled by signal enhancements through hyperpolarization. The parahydrogen-based method of signal amplification by...
6.
Pham P, Hilty C
Chem Sci
. 2023 Sep;
14(37):10258-10263.
PMID: 37772094
We demonstrate that low-field nuclear magnetic resonance provides a means for measuring biomacromolecular interactions without requiring a superconducting, or even a permanent magnet. A small molecule, 5-fluoropyridine-3-carboximidamide, is designed to...
7.
Mandal R, Pham P, Hilty C
Anal Chem
. 2022 Aug;
94(32):11375-11381.
PMID: 35921650
Hyperpolarization through signal amplification by reversible exchange (SABRE) provides a facile means to enhance nuclear magnetic resonance (NMR) signals of small molecules containing an N-heterocycle or other binding site for...
8.
Hilty C, Kurzbach D, Frydman L
Nat Protoc
. 2022 May;
17(7):1621-1657.
PMID: 35546640
NMR spectroscopy is the only method to access the structural dynamics of biomolecules at high (atomistic) resolution in their native solution state. However, this method's low sensitivity has two important...
9.
Pham P, Mandal R, Qi C, Hilty C
J Magn Reson Open
. 2022 May;
10-11.
PMID: 35530721
Advances in liquid state hyperpolarization methods have enabled new applications of high-resolution NMR spectroscopy. Utilizing strong signal enhancements from hyperpolarization allows performing NMR spectroscopy at low concentration, or with high...
10.
Hu J, Kim J, Hilty C
J Phys Chem Lett
. 2022 Apr;
13(17):3819-3823.
PMID: 35465675
The transfer of nuclear spin hyperpolarization from water to ligand F spins results in a transient signal change that is indicative of protein-ligand interaction. The F nucleus allows for background-free...