Christian Gnann
Overview
Explore the profile of Christian Gnann including associated specialties, affiliations and a list of published articles.
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10
Citations
1885
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Recent Articles
1.
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Chang Y, Gnann C, Steimbach R, Bayer F, Lechner S, Sakhteman A, et al.
Cell Rep
. 2024 May;
43(6):114272.
PMID: 38795348
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action...
2.
Mahdessian D, Cesnik A, Gnann C, Danielsson F, Stenstrom L, Arif M, et al.
Nature
. 2022 Aug;
608(7924):E32.
PMID: 35931766
No abstract available.
3.
Mund A, Coscia F, Kriston A, Hollandi R, Kovacs F, Brunner A, et al.
Nat Biotechnol
. 2022 May;
40(8):1231-1240.
PMID: 35590073
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here, we introduce Deep Visual Proteomics (DVP), which...
4.
Cho N, Cheveralls K, Brunner A, Kim K, Michaelis A, Raghavan P, et al.
Science
. 2022 Mar;
375(6585):eabi6983.
PMID: 35271311
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically...
5.
Mahdessian D, Cesnik A, Gnann C, Danielsson F, Stenstrom L, Arif M, et al.
Nature
. 2021 Feb;
590(7847):649-654.
PMID: 33627808
The cell cycle, over which cells grow and divide, is a fundamental process of life. Its dysregulation has devastating consequences, including cancer. The cell cycle is driven by precise regulation...
6.
Gnann C, Cesnik A, Lundberg E
Trends Cancer
. 2021 Jan;
7(4):278-282.
PMID: 33436349
Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells...
7.
Stenstrom L, Mahdessian D, Gnann C, Cesnik A, Ouyang W, Leonetti M, et al.
Mol Syst Biol
. 2020 Aug;
16(8):e9469.
PMID: 32744794
The nucleolus is essential for ribosome biogenesis and is involved in many other cellular functions. We performed a systematic spatiotemporal dissection of the human nucleolar proteome using confocal microscopy. In...
8.
Backstrom A, Kugel L, Gnann C, Xu H, Aslan J, Lundberg E, et al.
J Histochem Cytochem
. 2020 Jun;
68(7):473-489.
PMID: 32564662
Imaging is a powerful approach for studying protein expression and has the advantage over other methodologies in providing spatial information in situ at single cell level. Using immunofluorescence and confocal...
9.
Thul P, Akesson L, Wiking M, Mahdessian D, Geladaki A, Blal H, et al.
Science
. 2017 May;
356(6340).
PMID: 28495876
Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we present a comprehensive image-based map of...
10.
Skogs M, Stadler C, Schutten R, Hjelmare M, Gnann C, Bjork L, et al.
J Proteome Res
. 2016 Oct;
16(1):147-155.
PMID: 27723985
Antibodies are indispensible research tools, yet the scientific community has not adopted standardized procedures to validate their specificity. Here we present a strategy to systematically validate antibodies for immunofluorescence (IF)...