Christian Arquint
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Explore the profile of Christian Arquint including associated specialties, affiliations and a list of published articles.
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9
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531
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Recent Articles
1.
Arquint C, Cubizolles F, Morand A, Schmidt A, Nigg E
Open Biol
. 2018 Feb;
8(2).
PMID: 29445034
Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated. E3 ubiquitin ligases have been...
2.
Arquint C, Nigg E
Biochem Soc Trans
. 2016 Dec;
44(5):1253-1263.
PMID: 27911707
Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a...
3.
Graf F, Ludin P, Arquint C, Schmidt R, Schaub N, Kunz Renggli C, et al.
Cell Mol Life Sci
. 2016 Mar;
73(17):3387-400.
PMID: 26973180
Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate...
4.
Arquint C, Gabryjonczyk A, Imseng S, Bohm R, Sauer E, Hiller S, et al.
Elife
. 2015 Jul;
4.
PMID: 26188084
Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication. Here, we demonstrate that the SCL/TAL1 interrupting locus (STIL)...
5.
Arquint C, Gabryjonczyk A, Nigg E
Philos Trans R Soc Lond B Biol Sci
. 2014 Jul;
369(1650).
PMID: 25047618
Centrosomes-as well as the related spindle pole bodies (SPBs) of yeast-have been extensively studied from the perspective of their microtubule-organizing roles. Moreover, the biogenesis and duplication of these organelles have...
6.
Nigg E, cajanek L, Arquint C
FEBS Lett
. 2014 Jun;
588(15):2366-72.
PMID: 24951839
Centrioles function in the assembly of centrosomes and cilia. Structural and numerical centrosome aberrations have long been implicated in cancer, and more recent genetic evidence directly links centrosomal proteins to...
7.
Arquint C, Nigg E
Curr Biol
. 2014 Feb;
24(4):351-60.
PMID: 24485834
Background: STIL is a centriole duplication factor that localizes to the procentriolar cartwheel region, and mutations in STIL are associated with autosomal recessive primary microcephaly (MCPH). Excess STIL triggers centriole...
8.
Arquint C, Sonnen K, Stierhof Y, Nigg E
J Cell Sci
. 2012 Feb;
125(Pt 5):1342-52.
PMID: 22349698
Control of centriole number is crucial for genome stability and ciliogenesis. Here, we characterize the role of human STIL, a protein that displays distant sequence similarity to the centriole duplication...
9.
Montagner C, Arquint C, Cornelis G
J Bacteriol
. 2011 Oct;
193(24):6923-8.
PMID: 22001511
The type III secretion systems are contact-activated secretion systems that allow bacteria to inject effector proteins across eukaryotic cell membranes. The secretion apparatus, called injectisome or needle complex, includes a...