Christian A Bosken
Overview
Explore the profile of Christian A Bosken including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
510
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Recent Articles
1.
Greifenberg A, Honig D, Pilarova K, Duster R, Bartholomeeusen K, Bosken C, et al.
Cell Rep
. 2016 Jan;
14(2):320-31.
PMID: 26748711
Cyclin-dependent kinases regulate the cell cycle and transcription in higher eukaryotes. We have determined the crystal structure of the transcription kinase Cdk13 and its Cyclin K subunit at 2.0 Å...
2.
Ekumi K, Paculova H, Lenasi T, Pospichalova V, Bosken C, Rybarikova J, et al.
Nucleic Acids Res
. 2015 Feb;
43(5):2575-89.
PMID: 25712099
The Cdk12/CycK complex promotes expression of a subset of RNA polymerase II genes, including those of the DNA damage response. CDK12 is among only nine genes with recurrent somatic mutations...
3.
Itzen F, Greifenberg A, Bosken C, Geyer M
Nucleic Acids Res
. 2014 May;
42(12):7577-90.
PMID: 24860166
The bromodomain protein Brd4 regulates the transcription of signal-inducible genes. This is achieved by recruiting the positive transcription elongation factor P-TEFb to promoters by its P-TEFb interaction domain (PID). Here...
4.
Bosken C, Farnung L, Hintermair C, Schachter M, Vogel-Bachmayr K, Blazek D, et al.
Nat Commun
. 2014 Mar;
5:3505.
PMID: 24662513
Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription. Here we determine the crystal structure of Cdk12/CycK and analyse its requirements for...
5.
Czudnochowski N, Bosken C, Geyer M
Nat Commun
. 2012 May;
3:842.
PMID: 22588304
Phosphorylation of RNA polymerase II carboxy-terminal domain (CTD) in hepta-repeats YSPTSPS regulates eukaryotic transcription. Whereas Ser5 is phosphorylated in the initiation phase, Ser2 phosphorylation marks the elongation state. Here we...
6.
St Amour C, Sanso M, Bosken C, Lee K, Larochelle S, Zhang C, et al.
Mol Cell Biol
. 2012 Apr;
32(13):2372-83.
PMID: 22508988
In fission yeast, discrete steps in mRNA maturation and synthesis depend on a complex containing the 5'-cap methyltransferase Pcm1 and Cdk9, which phosphorylates the RNA polymerase II (Pol II) carboxyl-terminal...