Chris S Rae
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Explore the profile of Chris S Rae including associated specialties, affiliations and a list of published articles.
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16
Citations
1257
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Recent Articles
1.
Webster E, Peck N, Echeverri J, Gholizadeh S, Tang W, Woo R, et al.
ACS Nano
. 2024 Aug;
18(33):22181-22193.
PMID: 39105751
Nanoparticle-mediated mRNA delivery has emerged as a promising therapeutic modality, but its growth is still limited by the discovery and optimization of effective and well-tolerated delivery strategies. Lipid nanoparticles containing...
2.
Quaney M, Pritzl C, Luera D, Newth R, Knudson K, Saxena V, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(3):e2205049120.
PMID: 36634134
Stimulator of interferon genes (STING) signaling has been extensively studied in inflammatory diseases and cancer, while its role in T cell responses to infection is unclear. Using strains engineered to...
3.
Hanson W, Benanti E, Lemmens E, Liu W, Skoble J, Leong M, et al.
Infect Immun
. 2019 Jun;
87(8).
PMID: 31235641
Live-attenuated has shown encouraging potential as an immunotherapy platform in preclinical and clinical settings. However, additional safety measures will enable application across malignant and infectious diseases. Here, we describe a...
4.
Van Dis E, Sogi K, Rae C, Sivick K, Surh N, Leong M, et al.
Cell Rep
. 2018 May;
23(5):1435-1447.
PMID: 29719256
There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report that STING-activating cyclic dinucleotides (CDNs) formulated in a...
5.
Manzanillo P, Ayres J, Watson R, Collins A, Souza G, Rae C, et al.
Nature
. 2013 Sep;
501(7468):512-6.
PMID: 24005326
Ubiquitin-mediated targeting of intracellular bacteria to the autophagy pathway is a key innate defence mechanism against invading microbes, including the important human pathogen Mycobacterium tuberculosis. However, the ubiquitin ligases responsible...
6.
Witte C, Archer K, Rae C, Sauer J, Woodward J, Portnoy D
Adv Immunol
. 2012 Jan;
113:135-56.
PMID: 22244582
Acquired cell-mediated immunity to Listeria monocytogenes is induced by infection with live, replicating bacteria that grow in the host cell cytosol, whereas killed bacteria, or those trapped in a phagosome,...
7.
Golberg A, Rae C, Rubinsky B
Biochim Biophys Acta
. 2011 Nov;
1818(3):689-94.
PMID: 22100748
Genetically engineered cells with mutations of relevance to electroporation, cell membrane permeabilization by electric pulses, can become a promising new tool for fundamental research on this important biotechnology. Listeria monocytogenes...
8.
Rae C, Geissler A, Adamson P, Portnoy D
Infect Immun
. 2011 Jul;
79(9):3596-606.
PMID: 21768286
Listeria monocytogenes is a Gram-positive intracellular pathogen that is naturally resistant to lysozyme. Recently, it was shown that peptidoglycan modification by N-deacetylation or O-acetylation confers resistance to lysozyme in various...
9.
Waite J, Leiner I, Lauer P, Rae C, Barbet G, Zheng H, et al.
PLoS Pathog
. 2011 Apr;
7(3):e1001326.
PMID: 21455492
Host defense against the intracellular pathogen Listeria monocytogenes (Lm) requires innate and adaptive immunity. Here, we directly imaged immune cell dynamics at Lm foci established by dendritic cells in the...
10.
Sauer J, Sotelo-Troha K, von Moltke J, Monroe K, Rae C, Brubaker S, et al.
Infect Immun
. 2010 Nov;
79(2):688-94.
PMID: 21098106
Type I interferons (IFNs) are central regulators of the innate and adaptive immune responses to viral and bacterial infections. Type I IFNs are induced upon cytosolic detection of microbial nucleic...