Chris J McBain
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Explore the profile of Chris J McBain including associated specialties, affiliations and a list of published articles.
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106
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7923
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Recent Articles
1.
Shin J, Goldbach H, Burke D, Authement M, Swanson E, Bocarsly M, et al.
J Neurosci
. 2025 Jan;
45(11).
PMID: 39837662
Dopamine critically regulates neuronal excitability and promotes synaptic plasticity in the striatum, thereby shaping network connectivity and influencing behavior. These functions establish dopamine as a key neuromodulator, whose release properties...
2.
Furlanis E, Dai M, Garcia B, Vergara J, Pereira A, Pelkey K, et al.
bioRxiv
. 2024 Aug;
PMID: 39091835
In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools...
3.
Caccavano A, Vlachos A, McLean N, Kimmel S, Kim J, Vargish G, et al.
bioRxiv
. 2024 Feb;
PMID: 38313283
Within the adult rodent hippocampus, opioids suppress inhibitory parvalbumin-expressing interneurons (PV-INs), thus disinhibiting local micro-circuits. However, it is unknown if this disinhibitory motif is conserved in other cortical regions, species,...
4.
Banks E, Gutekunst C, Vargish G, Eaton A, Pelkey K, McBain C, et al.
Cell Rep Methods
. 2024 Jan;
4(1):100684.
PMID: 38211592
The mammalian brain contains a diverse array of cell types, including dozens of neuronal subtypes with distinct anatomical and functional characteristics. The brain leverages these neuron-type specializations to perform diverse...
5.
Pelkey K, Vargish G, Pellegrini L, Calvigioni D, Chapeton J, Yuan X, et al.
Neuron
. 2023 Sep;
111(23):3802-3818.e5.
PMID: 37776852
Various specialized structural/functional properties are considered essential for contextual memory encoding by hippocampal mossy fiber (MF) synapses. Although investigated to exquisite detail in model organisms, synapses, including MFs, have undergone...
6.
Camp C, Vlachos A, Klockner C, Krey I, Banke T, Shariatzadeh N, et al.
Commun Biol
. 2023 Sep;
6(1):952.
PMID: 37723282
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate a calcium-permeable component to fast excitatory neurotransmission. NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits (GRIN1) and two GluN2...
7.
Banks E, Gutekunst C, Vargish G, Eaton A, Pelkey K, McBain C, et al.
bioRxiv
. 2023 May;
PMID: 37214904
The mammalian brain contains the most diverse array of cell types of any organ, including dozens of neuronal subtypes with distinct anatomical and functional characteristics. The brain leverages these neuron-type-specializations...
8.
Vormstein-Schneider D, Lin J, Pelkey K, Chittajallu R, Guo B, Arias-Garcia M, et al.
Nat Neurosci
. 2022 Aug;
25(9):1247.
PMID: 35945454
No abstract available.
9.
Pouchelon G, Vergara J, McMahon J, Gorissen B, Lin J, Vormstein-Schneider D, et al.
Cell Rep Methods
. 2022 Jul;
2(6):100225.
PMID: 35784651
The ability to precisely control transgene expression is essential for basic research and clinical applications. Adeno-associated viruses (AAVs) are non-pathogenic and can be used to drive stable expression in virtually...
10.
Mackenzie-Gray Scott C, Pelkey K, Caccavano A, Abebe D, Lai M, Black K, et al.
Front Synaptic Neurosci
. 2022 Jun;
14:857608.
PMID: 35645763
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer's disease (AD). However, a...