Chris J Frangieh
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Explore the profile of Chris J Frangieh including associated specialties, affiliations and a list of published articles.
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13
Citations
508
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Recent Articles
1.
Frangieh C, Wilkinson M, Strebinger D, Strecker J, Walsh M, Faure G, et al.
Mob DNA
. 2024 Jun;
15(1):12.
PMID: 38863000
Eukaryotic retroelements are generally divided into two classes: long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons. A third class of eukaryotic retroelement, the Penelope-like elements (PLEs), has been well-characterized bioinformatically,...
2.
Yao D, Binan L, Bezney J, Simonton B, Freedman J, Frangieh C, et al.
Nat Biotechnol
. 2023 Oct;
42(8):1282-1295.
PMID: 37872410
Pooled CRISPR screens with single-cell RNA sequencing readout (Perturb-seq) have emerged as a key technique in functional genomics, but they are limited in scale by cost and combinatorial complexity. In...
3.
Strebinger D, Frangieh C, Friedrich M, Faure G, Macrae R, Zhang F
Nat Commun
. 2023 Aug;
14(1):5141.
PMID: 37612276
The delivery of genetic cargo remains one of the largest obstacles to the successful translation of experimental therapies, in large part due to the absence of targetable delivery vectors. Enveloped...
4.
Ho P, Melms J, Rogava M, Frangieh C, Pozniak J, Shah S, et al.
Cancer Cell
. 2023 Jun;
41(7):1207-1221.e12.
PMID: 37327789
The cell-autonomous balance of immune-inhibitory and -stimulatory signals is a critical process in cancer immune evasion. Using patient-derived co-cultures, humanized mouse models, and single-cell RNA-sequencing of patient melanomas biopsied before...
5.
Wilkinson M, Frangieh C, Macrae R, Zhang F
Science
. 2023 Apr;
380(6642):301-308.
PMID: 37023171
Non-long terminal repeat (non-LTR) retrotransposons, or long interspersed nuclear elements (LINEs), are an abundant class of eukaryotic transposons that insert into genomes by target-primed reverse transcription (TPRT). During TPRT, a...
6.
Yao D, Binan L, Bezney J, Simonton B, Freedman J, Frangieh C, et al.
bioRxiv
. 2023 Feb;
PMID: 36747806
Pooled CRISPR screens with single-cell RNA-seq readout (Perturb-seq) have emerged as a key technique in functional genomics, but are limited in scale by cost and combinatorial complexity. Here, we reimagine...
7.
Simmons S, Lithwick-Yanai G, Adiconis X, Oberstrass F, Iremadze N, Geiger-Schuller K, et al.
Nat Biotechnol
. 2022 Sep;
41(2):204-211.
PMID: 36109685
Here we introduce a mostly natural sequencing-by-synthesis (mnSBS) method for single-cell RNA sequencing (scRNA-seq), adapted to the Ultima genomics platform, and systematically benchmark it against current scRNA-seq technology. mnSBS uses...
8.
Melms J, Biermann J, Huang H, Wang Y, Nair A, Tagore S, et al.
Nature
. 2021 Oct;
598(7882):E2.
PMID: 34625743
No abstract available.
9.
Melms J, Biermann J, Huang H, Wang Y, Nair A, Tagore S, et al.
Nature
. 2021 Apr;
595(7865):114-119.
PMID: 33915568
Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2 infection, but the host response at the lung tissue level is poorly understood. Here we performed single-nucleus...
10.
Frangieh C, Melms J, Thakore P, Geiger-Schuller K, Ho P, Luoma A, et al.
Nat Genet
. 2021 Mar;
53(3):332-341.
PMID: 33649592
Resistance to immune checkpoint inhibitors (ICIs) is a key challenge in cancer therapy. To elucidate underlying mechanisms, we developed Perturb-CITE-sequencing (Perturb-CITE-seq), enabling pooled clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9...