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Chris A Fisher

Explore the profile of Chris A Fisher including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 198
Followers 0
Related Specialties
Hematology
Molecular Biology
Biology
Top 10 Co-Authors
Douglas R Higgs
Richard J Gibbons
Jackie A Sloane-Stanley
John M Old
Kevin Clark
Helena Ayyub
Michelle J Rugless
Sachith Mettananda
Jacqueline A Sharpe
Jon Kerry
Published In
Blood
EMBO Rep
Hemoglobin
Nat Commun
Hum Mol Genet
Affiliations
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Recent Articles
1.
Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays
Mettananda S, Clark K, Fisher C, Sloane-Stanley J, Gibbons R, Higgs D
Exp Hematol . 2018 Jan; 60:10-20. PMID: 29329925
In vitro erythroid differentiation systems are used to study the mechanisms underlying normal and abnormal erythropoiesis and to test the effects of various extracellular factors on erythropoiesis. The use of...
2.
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
Mettananda S, Fisher C, Hay D, Badat M, Quek L, Clark K, et al.
Nat Commun . 2017 Sep; 8(1):424. PMID: 28871148
β-Thalassemia is one of the most common inherited anemias, with no effective cure for most patients. The pathophysiology reflects an imbalance between α- and β-globin chains with an excess of...
3.
The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats
Nguyen D, Voon H, Xella B, Scott C, Clynes D, Babbs C, et al.
EMBO Rep . 2017 May; 18(6):914-928. PMID: 28487353
ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG) ATRX mutations are found in nearly all tumours that maintain their telomeres...
4.
Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Jones E, Pasricha S, Allen A, Evans P, Fisher C, Wray K, et al.
Blood . 2014 Dec; 125(5):873-80. PMID: 25519750
Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and...
5.
A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype
Rugless M, Fisher C, Old J, Sloane-Stanley J, Ayyub H, Higgs D, et al.
Hum Mol Genet . 2008 Jul; 17(19):3084-93. PMID: 18632685
We have characterized a newly identified 16.6 kb deletion which removes a significant proportion of the human alpha-globin cluster including the psizeta1, alpha(D), psialpha1 and alpha2-globin genes but leaves the...
6.
Hb Bart's in cord blood: an accurate indicator of alpha-thalassemia
Rugless M, Fisher C, Stephens A, Amos R, Mohammed T, Old J
Hemoglobin . 2006 Mar; 30(1):57-62. PMID: 16540417
We quantified Hb Bart's (gamma4) levels by high performance liquid chromatography (HPLC) in 103 fresh cord blood samples from Homerton Hospital, East London, UK. The alpha-globin gene arrangement was determined...
7.
Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations
Steensma D, Higgs D, Fisher C, Gibbons R
Blood . 2003 Nov; 103(6):2019-26. PMID: 14592816
Acquired somatic mutations in ATRX, an X-linked gene encoding a chromatin-associated protein, were recently identified in 4 patients with the rare subtype of myelodysplastic syndrome (MDS) associated with thalassemia (ATMDS)....