Chithra K Muraleedharan
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Explore the profile of Chithra K Muraleedharan including associated specialties, affiliations and a list of published articles.
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11
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190
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Recent Articles
1.
Choi E, Rajendiran T, Soni T, Park J, Aring L, Muraleedharan C, et al.
Nat Commun
. 2024 Jun;
15(1):4775.
PMID: 38839750
The metal ion transporter SLC39A8 is associated with physiological traits and diseases, including blood manganese (Mn) levels and inflammatory bowel diseases (IBD). The mechanisms by which SLC39A8 controls Mn homeostasis...
2.
Hayashi S, Muraleedharan C, Oku M, Tomar S, Hogan S, Quiros M, et al.
JCI Insight
. 2022 Oct;
7(23).
PMID: 36301666
Acute and chronic intestinal inflammation is associated with epithelial damage, resulting in mucosal wounds in the forms of erosions and ulcers in the intestinal tract. Intestinal epithelial cells (IECs) and...
3.
Fan S, Boerner K, Muraleedharan C, Nusrat A, Quiros M, Parkos C
JCI Insight
. 2022 Aug;
7(17).
PMID: 35943805
Junctional adhesion molecule-A (JAM-A) is expressed in several cell types, including epithelial and endothelial cells, as well as some leukocytes. In intestinal epithelial cells (IEC), JAM-A localizes to cell junctions...
4.
Sugihara K, Kitamoto S, Saraithong P, Nagao-Kitamoto H, Hoostal M, McCarthy C, et al.
Cell Rep
. 2022 Jul;
40(3):111093.
PMID: 35858565
Pathobionts employ unique metabolic adaptation mechanisms to maximize their growth in disease conditions. Adherent-invasive Escherichia coli (AIEC), a pathobiont enriched in the gut mucosa of patients with inflammatory bowel disease...
5.
Muraleedharan C, Mierzwiak J, Feier D, Nusrat A, Quiros M
J Vis Exp
. 2021 Feb;
(168).
PMID: 33616118
The intestinal epithelium is comprised of a single layer of cells that act as a barrier between the gut lumen and the interior of the body. Disruption in the continuity...
6.
Xu S, Coku A, Muraleedharan C, Harajli A, Mishulin E, Dahabra C, et al.
Front Cell Dev Biol
. 2021 Jan;
8:619641.
PMID: 33425925
Inherited retinal dystrophy (IRD) is a heterogenous blinding eye disease and affects more than 200,000 Americans and millions worldwide. By far, 270 protein-coding genes have been identified to cause IRD...
7.
Muraleedharan C, McClellan S, Ekanayaka S, Francis R, Zmejkoski A, Hazlett L, et al.
J Innate Immun
. 2019 Jan;
11(4):347-358.
PMID: 30625496
Macrophages (Mϕ) are an important component of the innate immune system; they play critical roles in the first line of defense to pathogen invasion and modulate adaptive immunity. MicroRNAs (miRNAs)...
8.
Geng R, Furness D, Muraleedharan C, Zhang J, Dabdoub A, Lin V, et al.
Sci Rep
. 2018 Dec;
8(1):18022.
PMID: 30575790
The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including the inner ear. Point-mutations in the seed sequence of miR-96 result in non-syndromic hearing...
9.
Zhuang P, Muraleedharan C, Xu S
Invest Ophthalmol Vis Sci
. 2017 Mar;
58(3):1646-1655.
PMID: 28297724
Purpose: Previously, we showed that microRNA-146 (miR-146) is a pivotal negative feedback regulator of multiple nuclear factor kappa-B (NF-κB) activation pathways in retinal endothelial cells (RECs). We hypothesized that miR-146...
10.
Muraleedharan C, McClellan S, Barrett R, Li C, Montenegro D, Carion T, et al.
Invest Ophthalmol Vis Sci
. 2016 Apr;
57(4):1506-17.
PMID: 27035623
Purpose: The microRNA-183/96/182 cluster (miR-183/96/182) plays important roles in sensory organs. Because the cornea is replete with sensory innervation, we hypothesized that miR-183/96/182 modulates the corneal response to bacterial infection...