Chisa Okada
Overview
Explore the profile of Chisa Okada including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
460
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Recent Articles
1.
Motosugi N, Sugiyama A, Okada C, Otomo A, Umezawa A, Akutsu H, et al.
Cell Rep Methods
. 2023 Jan;
2(12):100352.
PMID: 36590687
Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X chromosome inactivation (XCI) by long non-coding RNA (lncRNA) silencing, causing challenges in various applications of female hPSCs....
2.
Fukuda A, Hazelbaker D, Motosugi N, Hao J, Limone F, Beccard A, et al.
Stem Cell Reports
. 2021 Aug;
16(9):2138-2148.
PMID: 34416176
Human pluripotent stem cells (hPSCs) have proven to be valuable tools for both drug discovery and the development of cell-based therapies. However, the long non-coding RNA XIST, which is essential...
3.
Motosugi N, Okada C, Sugiyama A, Kawasaki T, Kimura M, Shiina T, et al.
Cell Rep
. 2021 Jun;
35(10):109222.
PMID: 34107248
Female human pluripotent stem cells (hPSCs) regularly show erosion of X chromosome inactivation featured by the loss of the long non-coding (lnc) RNA XIST and the accumulation of lncXACT. Here,...
4.
Nagata E, Fujii N, Kohara S, Okada C, Satoh T, Takekoshi S, et al.
Mol Biol Rep
. 2020 Sep;
47(9):6479-6485.
PMID: 32929655
We have previously reported that inositol hexakisphosphate kinase (InsPK)2 mediates cell death. InsPK2 is abundantly expressed in anterior horn cells of the mammalian spinal cord. We investigated the role of...
5.
Owada S, Endo H, Okada C, Yoshida K, Shida Y, Tatemichi M
Anticancer Res
. 2020 Sep;
40(9):5071-5079.
PMID: 32878795
Background/aim: Liver cancer has extremely poor prognosis. The cancerous tissues contain hypoxic regions, and the available drugs are poorly effective in hypoxic environments. NADPH oxidase 4 (NOX4), producing reactive oxygen...
6.
Watanabe N, Kidokoro M, Tanaka M, Inoue S, Tsuji T, Akatuska H, et al.
Cancer Cell Int
. 2020 Jun;
20:263.
PMID: 32581653
Background: The transmembrane glycoprotein podoplanin (PDPN) is upregulated in some tumors and has gained attention as a malignant tumor biomarker. PDPN molecules have platelet aggregation-stimulating domains and, are therefore, suggested...
7.
Hayashi H, Wang T, Tanaka M, Ogiwara S, Okada C, Ito M, et al.
PLoS One
. 2020 Jun;
15(6):e0234180.
PMID: 32511278
The autophagy-endolysosomal pathway is an evolutionally conserved degradation system that is tightly linked to a wide variety of physiological processes. Dysfunction of this system is associated with many pathological conditions...
8.
Iijima Y, Tanaka M, Suzuki S, Hauser D, Tanaka M, Okada C, et al.
iScience
. 2019 Dec;
22:318-335.
PMID: 31805436
Neuronal alternative splicing is a core mechanism for functional diversification. We previously found that STAR family proteins (SAM68, SLM1, SLM2) regulate spatiotemporal alternative splicing in the nervous system. However, the...
9.
Kakimoto Y, Okada C, Kawabe N, Sasaki A, Tsukamoto H, Nagao R, et al.
Sci Rep
. 2019 Mar;
9(1):3304.
PMID: 30824797
Lipofuscin is an intracellular aggregate of highly oxidized proteins that cannot be digested in the ubiquitin-proteasome system and accumulate mainly in lysosomes, especially in aged cells and pathological conditions. However,...
10.
Salybekov A, Kawaguchi A, Masuda H, Vorateera K, Okada C, Asahara T
PLoS One
. 2018 Nov;
13(11):e0203244.
PMID: 30485279
Background: Considering the impaired function of regenerative cells in myocardial infarction (MI) patients with comorbidities and associated risk factors, cell therapy to enhance the regenerative microenvironment was designed using regeneration-associated...