Chikara Dohno
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Explore the profile of Chikara Dohno including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
287
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Recent Articles
1.
Mikame Y, Toyama H, Dohno C, Wada T, Yamayoshi A
Commun Chem
. 2025 Jan;
8(1):18.
PMID: 39843926
Psoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been employed for the photodynamic regulation of gene expression by the photo-cross-linking of psoralen with the target DNA. However, stable triplex formation requires a consecutive...
2.
Dohno C, Kimura M, Fujiwara Y, Nakatani K
Nucleic Acids Res
. 2023 Aug;
51(18):9533-9541.
PMID: 37615580
Single-stranded RNA folds into a variety of secondary and higher-order structures. Distributions and dynamics of multiple RNA conformations are responsible for the biological function of RNA. We here developed a...
3.
Nakao J, Mikame Y, Eshima H, Yamamoto T, Dohno C, Wada T, et al.
Chembiochem
. 2023 Mar;
24(15):e202200789.
PMID: 36896628
Psoralens and their derivatives, such as trioxsalen, have unique crosslinking features to DNA. However, psoralen monomers do not have sequence-specific crosslinking ability with the target DNA. With the development of...
4.
Mikame Y, Sakai Y, Tahara R, Doi K, Yamamoto T, Dohno C, et al.
Chem Pharm Bull (Tokyo)
. 2022 Jul;
70(10):726-730.
PMID: 35896347
Several psoralen-conjugated oligonucleotides (Ps-Oligos) have been developed as photo-crosslinkable oligonucleotides targeting DNA or RNA. To avoid potential off-target effects, it is important to investigate the selective photo-crosslinking reactivity of Ps-Oligos...
5.
Hsu H, Murata A, Dohno C, Nakatani K, Chang K
Nucleic Acids Res
. 2022 May;
50(9):5369-5383.
PMID: 35511080
The -1 programmed ribosomal frameshifting (-1 PRF) has been explored as a gene regulatory circuit for synthetic biology applications. The -1 PRF usually uses an RNA pseudoknot structure as the...
6.
Mukherjee S, Murata A, Ishida R, Sugai A, Dohno C, Hamada M, et al.
Mol Ther Nucleic Acids
. 2022 Jan;
27:165-174.
PMID: 34976435
Selective targeting of biologically relevant RNAs with small molecules is a long-standing challenge due to the lack of clear understanding of the binding RNA motifs for small molecules. The standard...
7.
Konieczny P, Mukherjee S, Stepniak-Konieczna E, Taylor K, Niewiadomska D, Piasecka A, et al.
Nucleic Acids Res
. 2021 Aug;
49(16):9479-9495.
PMID: 34358321
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by a limited expansion of CGG repeats in the FMR1 gene. Degeneration of neurons in FXTAS cell models can...
8.
Simeth N, Kobayashi S, Kobauri P, Crespi S, Szymanski W, Nakatani K, et al.
Chem Sci
. 2021 Jul;
12(26):9207-9220.
PMID: 34276952
Short, complementary DNA single strands with mismatched base pairs cannot undergo spontaneous formation of duplex DNA (dsDNA). Mismatch binding ligands (MBLs) can compensate this effect, inducing the formation of the...
9.
Dohno C, Hagihara M, Binti Mohd Zaifuddin N, Nihei M, Saito K, Nakatani K
Chem Commun (Camb)
. 2021 Mar;
57(26):3235-3238.
PMID: 33646236
We demonstrated that a synthetic ligand NA, which selectively binds to a 5'-CAG-3'/5'-CAG-3' triad, induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. A thorough capillary...
10.
Matsumoto J, Nakamori M, Okamoto T, Murata A, Dohno C, Nakatani K
Chemistry
. 2020 May;
26(63):14305-14309.
PMID: 32449537
Expanded CUG repeat RNA in the dystrophia myotonia protein kinase (DMPK) gene causes myotonic dystrophy type 1 (DM1) and sequesters RNA processing proteins, such as the splicing factor muscleblind-like 1...