Chih-Kai Chao
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Explore the profile of Chih-Kai Chao including associated specialties, affiliations and a list of published articles.
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22
Citations
176
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Recent Articles
1.
Chao C, Blecha J, Polvoy I, Nillo R, Seo Y, Wilson D, et al.
Nucl Med Biol
. 2025 Feb;
142-143:108992.
PMID: 39913962
Objective And Background: The objective of this first-in-human study was to investigate the radiosynthesis, and the preliminary safety, biodistribution, and organ radiation dosimetry of the positron emission tomography (PET) imaging...
2.
[C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography Imaging in Rat
Hayes T, Chao C, Blecha J, Huynh T, VanBrocklin H, Zinn K, et al.
J Pharmacol Exp Ther
. 2023 Sep;
388(2):333-346.
PMID: 37770203
Synthesis of the acetylcholinesterase inhibitor paraoxon (POX) as a carbon-11 positron emission tomography tracer ([C]POX) and profiling in live rats is reported. Naïve rats intravenously injected with [C]POX showed a...
3.
Calderon-Garciduenas L, Stommel E, Lachmann I, Waniek K, Chao C, Gonzalez-Maciel A, et al.
Toxics
. 2022 Oct;
10(10).
PMID: 36287840
Environmental exposures to fine particulate matter (PM2.5) and ultrafine particle matter (UFPM) are associated with overlapping Alzheimer’s, Parkinson’s and TAR DNA-binding protein 43 (TDP-43) hallmark protein pathologies in young Metropolitan...
4.
Hitt D, Zwicker J, Chao C, Patel S, Gerdes J, Bridges R, et al.
Neurochem Res
. 2021 Jan;
46(3):494-503.
PMID: 33398639
The vesicular glutamate transporter (VGLUT) facilitates the uptake of glutamate (Glu) into neuronal vesicles. VGLUT has not yet been fully characterized pharmacologically but a body of work established that certain...
5.
Hayes T, Chao C, Blecha J, Huynh T, Zinn K, Thompson C, et al.
Chem Res Toxicol
. 2020 Dec;
34(1):63-69.
PMID: 33373198
Organophosphorus esters (OPs) were originally developed as pesticides but were repurposed as easily manufactured, inexpensive, and highly toxic chemical warfare agents. Acute OP toxicity is primarily due to inhibition of...
6.
Talley T, Chao C, Berkman C, Richardson R, Thompson C
Chem Res Toxicol
. 2020 Aug;
33(9):2455-2466.
PMID: 32833441
Studies with acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds with two chiral centers can serve as models or surrogates for understanding the rate, orientation, and postinhibitory mechanisms by the nerve...
7.
Hayes T, Blecha J, Chao C, Huynh T, VanBrocklin H, Zinn K, et al.
Ann N Y Acad Sci
. 2020 May;
1479(1):180-195.
PMID: 32436233
Oxime antidotes regenerate organophosphate-inhibited acetylcholinesterase (AChE). Although they share a common mechanism of AChE reactivation, the rate and amount of oxime that enters the brain are critical to the efficacy,...
8.
Thompson C, Chao C
Biochim Biophys Acta Biomembr
. 2020 Jan;
1862(12):183175.
PMID: 31923412
The vesicular glutamate transporters (VGLUTs) bind and move glutamate (Glu) from the cytosol into the lumen of synaptic vesicles using a H-electrochemical gradient (ΔpH and Δψ) generated by the vesicular...
9.
Bharate S, Chao C, Thompson C
Environ Toxicol Pharmacol
. 2019 Jul;
71:103218.
PMID: 31302432
A novel panel of oximes were synthesized, which have displayed varying degree of reactivation ability towards different organophosphorus (OP) modified cholinesterases. In the present article, we report a comparative reactivation...
10.
Calderon-Garciduenas L, Mukherjee P, Waniek K, Holzer M, Chao C, Thompson C, et al.
J Alzheimers Dis
. 2018 Nov;
66(4):1437-1451.
PMID: 30412505
Long-term exposure to fine particulate matter (PM2.5) and ozone (O3) above USEPA standards is associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) children exhibit subcortical pretangles in infancy...