Chien-Huang Lin
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Explore the profile of Chien-Huang Lin including associated specialties, affiliations and a list of published articles.
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121
Citations
1598
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Recent Articles
1.
Liu C, Lee H, Liou J, Hua H, Cheng W, Yuliani F, et al.
Eur J Pharmacol
. 2024 Jun;
977:176711.
PMID: 38839029
Histone deacetylase (HDAC) inhibitors are potential candidates for treating pulmonary fibrosis. MPT0E028, a novel pan-HDAC inhibitor, has been reported to exhibit antitumor activity in several cancer cell lines. In this...
2.
Cheng W, Chang P, Wu Y, Wang S, Chen C, Hsu F, et al.
Lung
. 2024 Apr;
202(3):343-356.
PMID: 38678499
Background: Severe asthma, characterized by inflammation and airway remodeling, involves fibroblast differentiation into myofibroblasts expressing α-SMA. This process leads to the production of fibronectin and connective tissue growth factor (CTGF),...
3.
Weng C, Lee M, Chao W, Lin Y, Chou C, Chen M, et al.
Mucosal Immunol
. 2023 Aug;
16(5):685-698.
PMID: 37536562
Although high-affinity immunoglobulin (Ig)E receptor (FcεRI) expression is upregulated in type 2 (T2)-high asthmatic airway epithelium, its functional role in airway epithelial dysfunction has not been elucidated. Here we report...
4.
Hua H, Wen H, Lee H, Weng C, Yuliani F, Kuo H, et al.
J Biomed Sci
. 2023 Jun;
30(1):40.
PMID: 37312162
Background: Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of...
5.
Cheng W, Kao S, Chen C, Yuliani F, Lin L, Lin C, et al.
Respir Res
. 2022 Dec;
23(1):381.
PMID: 36578010
Background: Airway fibrosis is one of the pathological characteristics of severe asthma. Transforming growth factor (TGF)-β has been known to promote epithelial-mesenchymal transition formation and to play a role in...
6.
Yuliani F, Chen J, Cheng W, Wen H, Chen B, Lin C
J Biomed Sci
. 2022 Nov;
29(1):95.
PMID: 36369000
Background: Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production...
7.
Lee M, Weng C, Chao W, Fang Y, Chung F, Lin C, et al.
Front Oncol
. 2022 Jun;
12:876051.
PMID: 35756605
Objective: Platelet activation and adhesion to cancer cells increase the release of multiple factors that contribute to EMT and chemoresistance. Elevated levels of D-dimer have been associated with poor clinical...
8.
Yeh L, Fang Y, Lee H, Liu C, Chen Y, Lo Y, et al.
Front Med (Lausanne)
. 2022 Jun;
9:794025.
PMID: 35665319
Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic mortality. The objective of this study was to investigate the therapeutic potential of a novel potent histone deacetylase...
9.
Cheng W, Lee K, Yu M, Chen J, Lin C, Chen B
Eur J Pharmacol
. 2021 Jul;
909:174385.
PMID: 34331953
Chronic obstructive asthma is characterized by airway fibrosis. Hypoxia and connective tissue growth factor (CTGF) play important roles in airway fibrosis. Preadipocyte factor-1 (Pref-1) participates in adipocyte differentiation and liver...
10.
Cheng W, Chen C, Chen J, Lin C, Chen B
Mol Med
. 2021 Jul;
27(1):69.
PMID: 34229599
Background: Several studies have reported that hypoxia plays a pathological role in severe asthma and tissue fibrosis. Our previous study showed that hypoxia induces A disintegrin and metalloproteinase 17 (ADAM17)...