Chi-Ho To
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Explore the profile of Chi-Ho To including associated specialties, affiliations and a list of published articles.
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65
Citations
747
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Recent Articles
11.
Pan L, Sze Y, Yang M, Tang J, Zhao S, Yi I, et al.
Front Immunol
. 2022 Mar;
13:837497.
PMID: 35265083
Retinal ischemia is a common cause of many retinal diseases, leading to irreversible vision impairment and blindness. Excessive neuroinflammation, including microglial activation and T-cell responses, has been identified as a...
12.
Abokyi S, Shan S, Lam C, Catral K, Pan F, Chan H, et al.
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445748
In age-related macular degeneration (AMD), hydroquinone (HQ)-induced oxidative damage in retinal pigment epithelium (RPE) is believed to be an early event contributing to dysregulation of inflammatory cytokines and vascular endothelial...
13.
Pan L, Cho K, Yi I, To C, Chen D, Do C
Oxid Med Cell Longev
. 2021 Jul;
2021:8377362.
PMID: 34306315
Ischemia is a common pathological condition present in many neurodegenerative diseases, including ischemic stroke, retinal vascular occlusion, diabetic retinopathy, and glaucoma, threatening the sight and lives of millions of people...
14.
Shan S, Do C, Lam T, Li H, Stamer W, To C
J Cell Physiol
. 2021 Jun;
236(12):8226-8238.
PMID: 34180057
Rho-kinase (ROCK) inhibitors, a novel class of anti-glaucoma agents, act by increasing the aqueous humor outflow through the conventional trabecular meshwork pathway. However, the downstream signaling consequences of the ROCK...
15.
Wang Q, Banerjee S, So C, Qiu C, Sze Y, Lam T, et al.
Front Cell Neurosci
. 2021 May;
15:664491.
PMID: 34025362
Low-dose atropine helps to control myopia progression with few side effects. However, the impact of atropine, a non-selective muscarinic Acetylcholine (ACh) receptor antagonist, on retinal ganglion cells (RGCs) remains unclear....
16.
Bian J, Sze Y, Tse D, To C, McFadden S, Lam C, et al.
Int J Mol Sci
. 2021 May;
22(9).
PMID: 33946922
Most of the previous myopic animal studies employed a single-candidate approach and lower resolution proteomics approaches that were difficult to detect minor changes, and generated limited systems-wide biological information. Hence,...
17.
Zhu Y, Bian J, Lu D, Wang Q, Gong B, Li K, et al.
Data Brief
. 2020 Dec;
33:106526.
PMID: 33304948
Atropine, a non-selective muscarinic antagonist, is known to slow down myopia progression in human adolescents and in several animal models. However, its underlying molecular mechanism is unclear. The present work...
18.
Khan M, Lam A, Armitage J, Hanna L, To C, Gentle A
J Clin Med
. 2020 Aug;
9(8).
PMID: 32781548
Mechanical tissue stresses are important contributors to the increased risk of sight-threatening pathology in larger, more myopic eyes. The contribution of altered ocular vasculature to the development of this pathology...
19.
Abokyi S, Shan S, To C, Chan H, Tse D
Oxid Med Cell Longev
. 2020 Aug;
2020:5296341.
PMID: 32774677
Trehalose is a natural dietary molecule that has shown antiaging and neuroprotective effects in several animal models of neurodegenerative diseases. The role of trehalose in the management of age-related macular...
20.
Shan S, Do C, Lam T, Li H, Stamer W, To C
Data Brief
. 2020 Jul;
31:105846.
PMID: 32613038
Rho-associated coiled coil-forming protein kinase (ROCK) inhibitors represent a novel class of anti-glaucoma drugs because of their ocular hypotensive effects. However, the underlying mechanisms responsible for lowering intraocular pressure (IOP)...