Cheuk-Ting Law
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Explore the profile of Cheuk-Ting Law including associated specialties, affiliations and a list of published articles.
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23
Citations
1756
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Recent Articles
1.
Law C, Burns K
bioRxiv
. 2025 Feb;
PMID: 39975348
Long interspersed element-1 (LINE-1, L1) retrotransposons are the most abundant protein-coding transposable elements (TE) in mammalian genomes, and have shaped genome content over 170 million years of evolution. LINE-1 is...
2.
Chan F, Yuen V, Shen J, Chin D, Law C, Wong B, et al.
Hepatology
. 2023 Dec;
80(2):295-311.
PMID: 38051950
Background And Aims: Chromatin assembly factor 1 (CAF-1) is a replication-dependent epigenetic regulator that controls cell cycle progression and chromatin dynamics. In this study, we aim to investigate the immunomodulatory...
3.
Cheu J, Chiu D, Kwan K, Yang C, Yuen V, Goh C, et al.
Sci Adv
. 2023 May;
9(18):eade5111.
PMID: 37146141
Hypoxia-induced adenosine creates an immunosuppressive tumor microenvironment (TME) and dampens the efficacy of immune checkpoint inhibitors (ICIs). We found that hypoxia-inducible factor 1 (HIF-1) orchestrates adenosine efflux through two steps...
4.
Yuen V, Chiu D, Law C, Cheu J, Chan C, Wong B, et al.
J Hepatol
. 2022 Dec;
78(2):376-389.
PMID: 36455783
Background & Aims: Tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) are the only two classes of FDA-approved drugs for individuals with advanced hepatocellular carcinoma (HCC). While TKIs confer...
5.
Wong L, Wei L, Wang G, Law C, Tsang F, Chin W, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Aug;
14(5):1053-1076.
PMID: 35944892
Background & Aims: Long noncoding RNAs (lncRNAs) are found to have profound impacts on diverse cellular processes. Although high-throughput sequencing studies have shown the differential lncRNA expression profiles between hepatocellular...
6.
Chan C, Chiu D, Yuen V, Law C, Wong B, Thu K, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(32):e2119514119.
PMID: 35914158
Deregulation of cell cycle is a typical feature of cancer cells. Normal cells rely on the strictly coordinated spindle assembly checkpoint (SAC) to maintain the genome integrity and survive. However,...
7.
Chan C, Yuen V, Chiu D, Goh C, Thu K, Cescon D, et al.
Hepatology
. 2022 Mar;
77(3):729-744.
PMID: 35302667
Background And Aims: Prognosis of HCC remains poor due to lack of effective therapies. Immune checkpoint inhibitors (ICIs) have delayed response and are only effective in a subset of patients....
8.
Shen J, Yang C, Zhang M, Chin D, Chan F, Law C, et al.
Cell Rep
. 2022 Feb;
38(5):110304.
PMID: 35108543
Cancer cells adapt to hypoxia through HIFs (hypoxia-inducible factors), which initiate the transcription of numerous genes for cancer cell survival in the hypoxia microenvironment. In this study, we find that...
9.
Berrens R, Yang A, Laumer C, Lun A, Bieberich F, Law C, et al.
Nat Biotechnol
. 2021 Nov;
40(4):546-554.
PMID: 34782740
Transposable elements (TEs) regulate diverse biological processes, from early development to cancer. Expression of young TEs is difficult to measure with next-generation, single-cell sequencing technologies because their highly repetitive nature...
10.
Cheng C, Tsang F, Wei L, Chen M, Chin D, Shen J, et al.
Commun Biol
. 2021 Jul;
4(1):888.
PMID: 34285329
Epigenetic deregulation plays an essential role in hepatocellular carcinoma (HCC) progression. Bromodomains are epigenetic "readers" of histone acetylation. Recently, bromodomain inhibitors have exhibited promising therapeutic potential for cancer treatment. Using...