Cheryl L Smith
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Explore the profile of Cheryl L Smith including associated specialties, affiliations and a list of published articles.
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20
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1267
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Recent Articles
11.
Yoshimura J, Ichikawa K, Shoura M, Artiles K, Gabdank I, Wahba L, et al.
Genome Res
. 2019 May;
29(6):1009-1022.
PMID: 31123080
was the first multicellular eukaryotic genome sequenced to apparent completion. Although this assembly employed a standard strain (N2), it used sequence data from several laboratories, with DNA propagated in bacteria...
12.
See K, Lan Y, Rhoades J, Jain R, Smith C, Epstein J
Development
. 2019 Feb;
146(3).
PMID: 30723106
Dynamic organization of chromatin within the three-dimensional nuclear space has been postulated to regulate gene expression and cell fate. Here, we define the genome-wide distribution of nuclear peripheral heterochromatin as...
13.
Artap S, Manderfield L, Smith C, Poleshko A, Aghajanian H, See K, et al.
Dev Biol
. 2018 May;
440(1):22-30.
PMID: 29727635
The Hippo signaling pathway has been implicated in control of cell and organ size, proliferation, and endothelial-mesenchymal transformation. This pathway impacts upon two partially redundant transcription cofactors, Yap and Taz,...
14.
Poleshko A, Shah P, Gupta M, Babu A, Morley M, Manderfield L, et al.
Cell
. 2017 Oct;
171(3):573-587.e14.
PMID: 29033129
Progenitor cells differentiate into specialized cell types through coordinated expression of lineage-specific genes and modification of complex chromatin configurations. We demonstrate that a histone deacetylase (Hdac3) organizes heterochromatin at the...
15.
Robison J, Smith C
Clin J Oncol Nurs
. 2016 Mar;
20(2):E34-40.
PMID: 26991721
Background: Patients with cancer commonly experience disease or treatment side effects, including pain, fatigue, nausea, and anxiety. An expanding body of literature supports the use of therapeutic massage (TM) as...
16.
Spies N, Smith C, Rodriguez J, Baker J, Batzoglou S, Sidow A
Elife
. 2015 Apr;
4:e05538.
PMID: 25871848
The effects of genetic variation on gene regulation in the developing mammalian embryo remain largely unexplored. To globally quantify these effects, we crossed two divergent mouse strains and asked how...
17.
Finn E, Smith C, Rodriguez J, Sidow A, Baker J
Dev Biol
. 2014 Mar;
390(1):80-92.
PMID: 24594094
To investigate the epigenetic landscape at the interface between mother and fetus, we provide a comprehensive analysis of parent-of-origin bias in the mouse placenta. Using F1 interspecies hybrids between mus...
18.
Kundaje A, Kyriazopoulou-Panagiotopoulou S, Libbrecht M, Smith C, Raha D, Winters E, et al.
Genome Res
. 2012 Sep;
22(9):1735-47.
PMID: 22955985
Gene regulation at functional elements (e.g., enhancers, promoters, insulators) is governed by an interplay of nucleosome remodeling, histone modifications, and transcription factor binding. To enhance our understanding of gene regulation,...
19.
Valouev A, Johnson S, Boyd S, Smith C, Fire A, Sidow A
Nature
. 2011 May;
474(7352):516-20.
PMID: 21602827
Nucleosomes are the basic packaging units of chromatin, modulating accessibility of regulatory proteins to DNA and thus influencing eukaryotic gene regulation. Elaborate chromatin remodelling mechanisms have evolved that govern nucleosome...
20.
Beck A, Weng Z, Witten D, Zhu S, Foley J, Lacroute P, et al.
PLoS One
. 2010 Jan;
5(1):e8768.
PMID: 20098735
Gene expression microarrays are the most widely used technique for genome-wide expression profiling. However, microarrays do not perform well on formalin fixed paraffin embedded tissue (FFPET). Consequently, microarrays cannot be...