Chenrui An
Overview
Explore the profile of Chenrui An including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
148
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Recent Articles
1.
Xie H, An C, Bai B, Luo J, Sun N, Ci B, et al.
Cell Stem Cell
. 2025 Jan;
32(3):409-425.e8.
PMID: 39814012
Blastoids are a promising model for studying early human embryogenesis, but current models have limitations in post-implantation development and lack comprehensive epigenetic assessments, especially regarding genomic imprinting. These issues can...
2.
Ma J, Zheng S, An C, Han H, Li Q, Huang Y, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(45):e2405886121.
PMID: 39471230
Mutations modification enzymes including the tRNA N-methylguanosine (mG) methyltransferase complex component WDR4 were frequently found in patients with neural disorders, while the pathogenic mechanism and therapeutic intervention strategies are poorly...
3.
Shang Y, Wang N, Wang H, An C, Sun W
BMC Biol
. 2024 Sep;
22(1):210.
PMID: 39294757
Background: X chromosome inactivation (XCI) is a critical epigenetic event for dosage compensation of X-linked genes in female mammals, ensuring developmental stability. A robust in vitro model is required for...
4.
Lyu X, Cui Y, Kong Y, Yang M, Shen H, Liao S, et al.
Mol Cell
. 2024 Jul;
84(14):2665-2681.e13.
PMID: 38955180
During implantation, embryos undergo an unpolarized-to-polarized transition to initiate postimplantation morphogenesis. However, the underlying molecular mechanism is unknown. Here, we identify a transient transcriptional activation governing embryonic morphogenesis and pluripotency...
5.
Luo Y, An C, Zhong K, Zhou P, Li D, Liu H, et al.
J Adv Res
. 2024 Feb;
68:115-129.
PMID: 38402947
Introduction: Advanced maternal age is associated with reduced implantation and pregnancy rates, yet the underlying mechanisms remain poorly understood, and research models are limited. Objectives: Here, we aim to elucidate...
6.
Wang Y, Yang N, Sun W, Zhao C, Hu X, Lu S, et al.
Cell Prolif
. 2023 May;
56(5):e13468.
PMID: 37199042
Different pluripotent cell types have been established by capturing pluripotency in different states. Human extended pluripotent stem cells (hEPSCs), recently established by two independent studies, have the capability of differentiating...
7.
Zhang Y, An C, Yu Y, Lin J, Jin L, Li C, et al.
Cell Prolif
. 2022 Jul;
55(11):e13317.
PMID: 35880490
Objectives: This study aims to optimize the human extended pluripotent stem cell (EPSC) to trophectoderm (TE)-like cell induction with addition of EGF and improve the quality of the reconstructing blastoids....
8.
Fan Y, Min Z, Alsolami S, Ma Z, Zhang E, Chen W, et al.
Cell Discov
. 2021 Sep;
7(1):81.
PMID: 34489415
Human blastocysts are comprised of the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm, all of which are essential for early development and organ formation. However,...
9.
An C, Feng G, Zhang J, Cao S, Wang Y, Wang N, et al.
Cell Stem Cell
. 2020 Jul;
27(3):482-497.e4.
PMID: 32673569
Primed and naive human embryonic stem cells (hESCs) do not fully recapitulate the X chromosome status observed in human preimplantation epiblast and fail to initiate random X chromosome inactivation (XCI)...
10.
Wang Y, Huang J, Gong L, Yu D, An C, Bunpetch V, et al.
iScience
. 2019 Apr;
15:66-78.
PMID: 31030183
A low surface expression level of human leukocyte antigen class I (HLA-I) ensures that the mesenchymal stem cells (MSCs) escape from the allogeneic recipients' immunological surveillance. Here, we discovered that...