Charlotte Wallaeys
Overview
Explore the profile of Charlotte Wallaeys including associated specialties, affiliations and a list of published articles.
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13
Citations
120
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Recent Articles
1.
Timmermans S, Wallaeys C, De Beul S, Garcia-Gonzales N, Libert C
Front Immunol
. 2025 Feb;
16:1543059.
PMID: 39981239
Introduction: In mammals, Paneth cells, located in the crypts of the small intestine, produceantimicrobial peptides that serve to keep the intestinal microbiome under control. a-Defensins are the primary antimicrobial peptides...
2.
Timmermans S, Wallaeys C, Garcia-Gonzalez N, Pollaris L, Saeys Y, Libert C
Cells
. 2024 Sep;
13(17.
PMID: 39273007
The small intestinal crypts harbor secretory Paneth cells (PCs) which express bactericidal peptides that are crucial for maintaining intestinal homeostasis. Considering the diverse environmental conditions throughout the course of the...
3.
Wallaeys C, Garcia-Gonzalez N, Timmermans S, Vandewalle J, Vanderhaeghen T, De Beul S, et al.
Cell Host Microbe
. 2024 Sep;
32(10):1725-1743.e7.
PMID: 39243761
The cytokine tumor necrosis factor (TNF) plays important roles in limiting infection but is also linked to sepsis. The mechanisms underlying these paradoxical roles are unclear. Here, we show that...
4.
Vanderhaeghen T, Timmermans S, Eggermont M, Watts D, Vandewalle J, Wallaeys C, et al.
Front Immunol
. 2023 Apr;
14:1124011.
PMID: 37006237
Introduction: Polymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and...
5.
Wallaeys C, Garcia-Gonzalez N, Libert C
EMBO Mol Med
. 2022 Dec;
15(2):e16427.
PMID: 36573340
Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis....
6.
Vanderhaeghen T, Timmermans S, Watts D, Paakinaho V, Eggermont M, Vandewalle J, et al.
EMBO Rep
. 2021 Oct;
23(1):e53083.
PMID: 34699114
Here, we investigate the impact of hypoxia on the hepatic response of glucocorticoid receptor (GR) to dexamethasone (DEX) in mice via RNA-sequencing. Hypoxia causes three types of reprogramming of GR:...
7.
Van Wyngene L, Vanderhaeghen T, Petta I, Timmermans S, Corbeels K, Van der Schueren B, et al.
iScience
. 2021 Aug;
24(7):102790.
PMID: 34337361
The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body's response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB...
8.
Vandewalle J, Timmermans S, Paakinaho V, Vancraeynest L, Dewyse L, Vanderhaeghen T, et al.
Cell Metab
. 2021 Jul;
33(9):1763-1776.e5.
PMID: 34302744
Sepsis is a potentially lethal syndrome resulting from a maladaptive response to infection. Upon infection, glucocorticoids are produced as a part of the compensatory response to tolerate sepsis. This tolerance...
9.
Vanderhaeghen T, Wallaeys C, Libert C
EMBO Mol Med
. 2020 Dec;
13(1):e13589.
PMID: 33332738
Sepsis causes unacceptably high amounts of deaths worldwide. It is a huge unmet medical need, and new therapeutic interventions for sepsis and septic shock are urgently needed. By studying the...
10.
Souffriau J, Timmermans S, Vanderhaeghen T, Wallaeys C, Van Looveren K, Aelbrecht L, et al.
EMBO Mol Med
. 2020 Sep;
12(10):e11917.
PMID: 32914580
The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF-induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc...