Charlie Marvalim
Overview
Explore the profile of Charlie Marvalim including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
184
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0
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Recent Articles
1.
Cheng H, Chong Y, Lim E, Lee X, Pang Q, Novera W, et al.
Neuro Oncol
. 2024 Feb;
26(7):1247-1261.
PMID: 38366847
Background: Precision treatment of glioblastoma is increasingly focused on molecular subtyping, with the mesenchymal subtype particularly resistant to temozolomide. Here, we aim to develop a targeted therapy for temozolomide resensitization...
2.
Marvalim C, Datta A, Lee S
Theranostics
. 2023 Mar;
13(4):1421-1442.
PMID: 36923534
The transcription factor p53 is an important regulator of a multitude of cellular processes. In the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest,...
3.
Cheng H, Marvalim C, Zhu P, Law C, Low Z, Chong Y, et al.
Theranostics
. 2021 Apr;
11(11):5127-5142.
PMID: 33859738
Hypoxic microenvironment is a hallmark of solid tumors, especially glioblastoma. The strong reliance of glioma-propagating cells (GPCs) on hypoxia-induced survival advantages is potentially exploitable for drug development. To identify key...
4.
Yap W, Shyu Jr P, Gaspar M, Jesch S, Marvalim C, Prinz W, et al.
J Cell Sci
. 2020 Oct;
133(21).
PMID: 33033181
Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage-inducing transmembrane (FIT; also known as FITM) family induces LD formation. Here, we establish a model...
5.
Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence
Cheng H, Tan W, Low Z, Marvalim C, Lee J, Tan N
Int J Mol Sci
. 2019 Oct;
20(20).
PMID: 31614690
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting...
6.
Shyu Jr P, Ng B, Ho N, Chaw R, Seah Y, Marvalim C, et al.
Sci Rep
. 2019 Jun;
9(1):8637.
PMID: 31201345
Phospholipid homeostasis in biological membranes is essential to maintain functions of organelles such as the endoplasmic reticulum. Phospholipid perturbation has been associated to cellular stress responses. However, in most cases,...
7.
Marvalim C, Wong J, Sutiman N, Lim W, Tan S, Kanesvaran R, et al.
Pharmacogenet Genomics
. 2017 Jan;
27(3):120-123.
PMID: 28059867
The critical role of lysine demethylase 4A (KDM4A), in regulating chromatin structure and consequently in driving cellular proliferation and oncogenesis has been the focus of recent studies. Non-small-cell lung cancer...