Charles W M Roberts
Overview
Explore the profile of Charles W M Roberts including associated specialties, affiliations and a list of published articles.
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Articles
79
Citations
10632
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Recent Articles
1.
Mittal P, Myers J, Carter R, Radko-Juettner S, Malone H, Rosikiewicz W, et al.
Nat Commun
. 2024 Aug;
15(1):7303.
PMID: 39181868
Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed...
2.
Malone H, Roberts C
Nat Rev Drug Discov
. 2024 Jul;
23(9):661-681.
PMID: 39014081
Large-scale cancer genome sequencing studies have revealed that chromatin regulators are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations in genes that encode subunits of...
3.
Chen X, Yang W, Roberts C, Zhang J
Nat Rev Cancer
. 2024 May;
24(7):513.
PMID: 38773327
No abstract available.
4.
Chen X, Yang W, Roberts C, Zhang J
Nat Rev Cancer
. 2024 May;
24(6):382-398.
PMID: 38698126
In the past two decades, technological advances have brought unprecedented insights into the paediatric cancer genome revealing characteristics distinct from those of adult cancer. Originating from developing tissues, paediatric cancers...
5.
Radko-Juettner S, Yue H, Myers J, Carter R, Robertson A, Mittal P, et al.
Nature
. 2024 Apr;
629(8012):E12.
PMID: 38684813
No abstract available.
6.
Radko-Juettner S, Yue H, Myers J, Carter R, Robertson A, Mittal P, et al.
Nature
. 2024 Mar;
628(8007):442-449.
PMID: 38538798
Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic because the tumour-suppressor proteins are no longer present to be...
7.
Flores-Toro J, Jagu S, Armstrong G, Arons D, Aune G, Chanock S, et al.
J Clin Oncol
. 2023 Jun;
41(24):4045-4053.
PMID: 37267580
Data-driven basic, translational, and clinical research has resulted in improved outcomes for children, adolescents, and young adults (AYAs) with pediatric cancers. However, challenges in sharing data between institutions, particularly in...
8.
Zhu Z, Chen X, Guo A, Manzano T, Walsh P, Wills K, et al.
Nature
. 2023 May;
618(7963):180-187.
PMID: 37225980
For cells to initiate and sustain a differentiated state, it is necessary that a 'memory' of this state is transmitted through mitosis to the daughter cells. Mammalian switch/sucrose non-fermentable (SWI/SNF)...
9.
Guo A, Huang H, Zhu Z, Chen M, Shi H, Yuan S, et al.
Nature
. 2022 Jun;
607(7917):135-141.
PMID: 35732731
The identification of mechanisms to promote memory T (T) cells has important implications for vaccination and anti-cancer immunotherapy. Using a CRISPR-based screen for negative regulators of T cell generation in...
10.
Drosos Y, Myers J, Xu B, Mathias K, Beane E, Radko-Juettner S, et al.
Mol Cell
. 2022 May;
82(13):2472-2489.e8.
PMID: 35537449
Disruption of antagonism between SWI/SNF chromatin remodelers and polycomb repressor complexes drives the formation of numerous cancer types. Recently, an inhibitor of the polycomb protein EZH2 was approved for the...