Charles W Emala Sr
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Explore the profile of Charles W Emala Sr including associated specialties, affiliations and a list of published articles.
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25
Citations
524
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Recent Articles
11.
Brown A, Danielsson J, Townsend E, Zhang Y, Perez-Zoghbi J, Emala Sr C, et al.
Am J Physiol Lung Cell Mol Physiol
. 2016 Jan;
310(8):L747-58.
PMID: 26773068
Enhanced contractility of airway smooth muscle (ASM) is a major pathophysiological characteristic of asthma. Expanding the therapeutic armamentarium beyond β-agonists that target ASM hypercontractility would substantially improve treatment options. Recent...
12.
Mizuta K, Zhang Y, Mizuta F, Hoshijima H, Shiga T, Masaki E, et al.
Am J Physiol Lung Cell Mol Physiol
. 2015 Sep;
309(9):L970-82.
PMID: 26342087
Obesity is one of the major risk factors for asthma. Previous studies have demonstrated that free fatty acid levels are elevated in the plasma of obese individuals. Medium- and long-chain...
13.
Lazrak A, Creighton J, Yu Z, Komarova S, Doran S, Aggarwal S, et al.
Am J Physiol Lung Cell Mol Physiol
. 2015 Mar;
308(9):L891-903.
PMID: 25747964
Chlorine (Cl2) inhalation induces severe oxidative lung injury and airway hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl2 reacts with epithelial lining fluid, forming by-products that damage hyaluronan,...
14.
Gallos G, Yocum G, Siviski M, Yim P, Fu X, Poe M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2015 Feb;
308(9):L931-42.
PMID: 25659897
The clinical need for novel bronchodilators for the treatment of bronchoconstrictive diseases remains a major medical issue. Modulation of airway smooth muscle (ASM) chloride via GABAA receptor activation to achieve...
15.
Yim P, Gallos G, Perez-Zoghbi J, Trice J, Zhang Y, Siviski M, et al.
J Smooth Muscle Res
. 2014 Mar;
49:112-24.
PMID: 24662476
Enhanced airway smooth muscle (ASM) contraction is an important component in the pathophysiology of asthma. We have shown that ligand gated chloride channels modulate ASM contractile tone during the maintenance...
16.
Srivastava K, Sampson H, Emala Sr C, Li X
Am J Physiol Lung Cell Mol Physiol
. 2013 Oct;
305(12):L1002-10.
PMID: 24163140
Our previous studies have shown that the anti-asthma traditional Chinese medicine herbal formula ASHMI (anti-asthma simplified herbal medicine intervention) inhibits acetylcholine-induced contractions of tracheal rings from ovalbumin-sensitized and naive mice...
17.
Gallos G, Remy K, Danielsson J, Funayama H, Fu X, Chang H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2013 Sep;
305(9):L625-34.
PMID: 23997176
Airway smooth muscle hyperresponsiveness is a key component in the pathophysiology of asthma. Although calcium-activated chloride channel (CaCC) flux has been described in many cell types, including human airway smooth...
18.
Townsend E, Emala Sr C
Am J Physiol Lung Cell Mol Physiol
. 2013 Jul;
305(5):L396-403.
PMID: 23873842
Asthma is a disease of the airways with symptoms including exaggerated airway narrowing and airway inflammation. Early asthma therapies used methylxanthines to relieve symptoms, in part, by inhibiting cyclic nucleotide...
19.
Gallos G, Yim P, Chang S, Zhang Y, Xu D, Cook J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2011 Sep;
302(2):L248-56.
PMID: 21949156
The prevalence of asthma has taken on pandemic proportions. Since this disease predisposes patients to severe acute airway constriction, novel mechanisms capable of promoting airway smooth muscle relaxation would be...
20.