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Charles Mwansambo

Explore the profile of Charles Mwansambo including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 70
Citations 2560
Followers 0
Related Specialties
General Medicine
Public Health
Science
Top 10 Co-Authors
Anthony Costello
Tim Colbourn
Carina King
Eric D McCollum
Neil French
Norman Lufesi
Robert S Heyderman
Bejoy Nambiar
Naor Bar-Zeev
Tambosi Phiri
Published In
PLoS One
BMJ Open
Lancet
PLoS Med
Lancet Glob Health
Affiliations
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Recent Articles
11.
External validation of the RISC, RISC-Malawi, and PERCH clinical prediction rules to identify risk of death in children hospitalized with pneumonia
Rees C, Hooli S, King C, McCollum E, Colbourn T, Lufesi N, et al.
J Glob Health . 2021 Nov; 11:04062. PMID: 34737862
Background: Existing scores to identify children at risk of hospitalized pneumonia-related mortality lack broad external validation. Our objective was to externally validate three such risk scores. Methods: We applied the...
12.
Disruptions in maternal and child health service utilization during COVID-19: analysis from eight sub-Saharan African countries
Shapira G, Ahmed T, Drouard S, Fernandez P, Kandpal E, Nzelu C, et al.
Health Policy Plan . 2021 Jun; 36(7):1140-1151. PMID: 34146394
The coronavirus-19 pandemic and its secondary effects threaten the continuity of essential health services delivery, which may lead to worsened population health and a protracted public health crisis. We quantify...
13.
Impact and effectiveness of 13-valent pneumococcal conjugate vaccine on population incidence of vaccine and non-vaccine serotype invasive pneumococcal disease in Blantyre, Malawi, 2006-18: prospective observational time-series and case-control...
Bar-Zeev N, Swarthout T, Everett D, Alaerts M, Msefula J, Brown C, et al.
Lancet Glob Health . 2021 Jun; 9(7):e989-e998. PMID: 34143997
Background: The population impact of pneumococcal conjugate vaccines (PCVs) depends on direct and indirect protection. Following Malawi's introduction of the 13-valent PCV (PCV13) in 2011, we examined its impact on...
14.
A pragmatic health centre-based evaluation comparing the effectiveness of a PCV13 schedule change from 3+0 to 2+1 in a high pneumococcal carriage and disease burden setting in Malawi: a study protocol
Swarthout T, Ibarz-Pavon A, Kawalazira G, Sinjani G, Chirombo J, Gori A, et al.
BMJ Open . 2021 Jun; 11(6):e050312. PMID: 34140345
Introduction: (the pneumococcus) is commonly carried as a commensal bacterium in the nasopharynx but can cause life-threatening disease. Transmission occurs by human respiratory droplets and interruption of this process provides...
15.
Predictive value of pulse oximetry for mortality in infants and children presenting to primary care with clinical pneumonia in rural Malawi: A data linkage study
Colbourn T, King C, Beard J, Phiri T, Mdala M, Zadutsa B, et al.
PLoS Med . 2020 Oct; 17(10):e1003300. PMID: 33095763
Background: The mortality impact of pulse oximetry use during infant and childhood pneumonia management at the primary healthcare level in low-income countries is unknown. We sought to determine mortality outcomes...
16.
Evaluation of Pneumococcal Serotyping of Nasopharyngeal-Carriage Isolates by Latex Agglutination, Whole-Genome Sequencing (PneumoCaT), and DNA Microarray in a High-Pneumococcal-Carriage-Prevalence Population in Malawi
Swarthout T, Gori A, Bar-Zeev N, Kamngona A, Mwalukomo T, Bonomali F, et al.
J Clin Microbiol . 2020 Oct; 59(1). PMID: 33087431
Accurate assessment of the serotype distribution associated with pneumococcal colonization and disease is essential for evaluating and formulating pneumococcal vaccines and for informing vaccine policy. For this reason, we evaluated...
17.
Population impact and effectiveness of sequential 13-valent pneumococcal conjugate and monovalent rotavirus vaccine introduction on infant mortality: prospective birth cohort studies from Malawi
King C, Bar-Zeev N, Phiri T, Beard J, Mvula H, Crampin A, et al.
BMJ Glob Health . 2020 Sep; 5(9). PMID: 32912855
Background: Pneumococcal conjugate vaccine (PCV) and rotavirus vaccine (RV) are key tools for reducing common causes of infant mortality. However, measurement of population-level mortality impact is lacking from sub-Saharan Africa....
18.
High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi
Swarthout T, Fronterre C, Lourenco J, Obolski U, Gori A, Bar-Zeev N, et al.
Nat Commun . 2020 May; 11(1):2222. PMID: 32376860
There are concerns that pneumococcal conjugate vaccines (PCVs) in sub-Saharan Africa sub-optimally interrupt Streptococcus pneumoniae vaccine-serotype (VT) carriage and transmission. Here we assess PCV carriage using rolling, prospective nasopharyngeal carriage...
19.
The Epidemiology of Hypoxemic Pneumonia among Young Infants in Malawi
Hooli S, King C, Zadutsa B, Nambiar B, Makwenda C, Masache G, et al.
Am J Trop Med Hyg . 2020 Jan; 102(3):676-683. PMID: 31971153
We describe hypoxemic pneumonia prevalence in outpatient and inpatient settings, in-hospital mortality, and clinical guideline performance for identifying hypoxemia in young infants in Malawi. In this retrospective analysis of a...
20.
Use of bubble continuous positive airway pressure (bCPAP) in the management of critically ill children in a Malawian paediatric unit: an observational study
Myers S, Dinga P, Anderson M, Schubert C, Mlotha R, Phiri A, et al.
BMJ Open Respir Res . 2019 Apr; 6(1):e000280. PMID: 30956794
Introduction: In low-resource countries, respiratory failure is associated with a high mortality risk among critically ill children. We evaluated the role of bubble continuous positive airway pressure (bCPAP) in the...