Charles Edward Jefford
Overview
Explore the profile of Charles Edward Jefford including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
256
Followers
0
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Recent Articles
1.
Ryser S, Dizin E, Jefford C, Delaval B, Gagos S, Christodoulidou A, et al.
Cancer Res
. 2009 Jan;
69(3):1125-34.
PMID: 19176389
The BRCA1-associated ring domain protein 1 (BARD1) interacts with BRCA1 via its RING finger domain. The BARD1-BRCA1 complex participates in DNA repair, cell cycle control, genomic stability, and mitotic spindle...
2.
Li L, Ryser S, Dizin E, Pils D, Krainer M, Jefford C, et al.
Cancer Res
. 2007 Dec;
67(24):11876-85.
PMID: 18089818
BARD1 is required for protein stability and tumor suppressor functions of BRCA1, which depend on the ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. The NH(2)-terminal RING domains of both proteins...
3.
Irminger-Finger I, Jefford C
Nat Rev Cancer
. 2006 Apr;
6(5):382-91.
PMID: 16633366
It has been over a decade since mutations in BRCA1 and BRCA2 were found to be associated with a small number of familial breast cancer cases. BRCA1 is a large...
4.
Jefford C, Irminger-Finger I
Crit Rev Oncol Hematol
. 2006 Apr;
59(1):1-14.
PMID: 16600619
Most tumours arise through clonal selection and waves of expansion of a somatic cell that has acquired genetic alterations in essential genes either controlling cell death or cell proliferation. Furthermore,...
5.
Feki A, Jefford C, Berardi P, Wu J, Cartier L, Krause K, et al.
Oncogene
. 2005 Mar;
24(23):3726-36.
PMID: 15782130
The BRCA1-associated RING domain protein BARD1 acts with BRCA1 in double-strand break repair and ubiquitination. BARD1 plays a role as mediator of apoptosis by binding to and stabilizing p53, and...
6.
Feki A, Jefford C, Jefford C, Durand P, Harb J, Lucas H, et al.
Biol Reprod
. 2004 Jul;
71(5):1614-24.
PMID: 15240424
The BRCA1-binding RING-finger domain protein BARD1 may act conjointly with BRCA1 in DNA repair and in ubiquitination, but it may also induce apoptosis in a BRCA1-independent manner. In this study,...
7.
Jefford C, Feki A, Harb J, Krause K, Irminger-Finger I
Oncogene
. 2004 Apr;
23(20):3509-20.
PMID: 15077185
The tumor suppressor protein BARD1 plays a dual role in response to genotoxic stress: DNA repair as a BARD1-BRCA1 heterodimer and induction of apoptosis in a BRCA1-independent manner. We have...