Charles D Searles
Overview
Explore the profile of Charles D Searles including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
38
Citations
1137
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Mitchell A, Gray W, Schroeder M, Yi H, Taylor J, Dillard R, et al.
PLoS One
. 2016 Oct;
11(10):e0163582.
PMID: 27760197
Background: Red blood cell (RBC) transfusions are a common, life-saving therapy for many patients, but they have also been associated with poor clinical outcomes. We identified unusual, pleomorphic structures in...
12.
Mitchell A, Gray W, Hayek S, Ko Y, Thomas S, Rooney K, et al.
Sci Rep
. 2016 Sep;
6:32651.
PMID: 27623086
Extracellular miRNAs are detectable in biofluids and represent a novel class of disease biomarker. Although many studies have utilized archived plasma for miRNA biomarker discovery, the effects of processing and...
13.
Mitchell A, Alexy T, Rubinsztain L, Iqbal A, Shah A, Zafari A, et al.
Am J Med
. 2016 Jan;
129(5):e17-8.
PMID: 26797082
No abstract available.
14.
Gray W, Mitchell A, Searles C
MethodsX
. 2015 Nov;
2:360-7.
PMID: 26543819
Extracellular, membrane vesicles (microvesicles, exosomes) are secreted by cells and may serve as mediators of intercellular communication. Methods for detecting them by flow cytometry have included the use of agents...
15.
Green D, Murphy T, Kang B, Searles C, Hart C
PLoS One
. 2015 Jul;
10(7):e0133391.
PMID: 26208095
Pulmonary hypertension (PH) is a progressive and often fatal disorder whose pathogenesis involves pulmonary artery smooth muscle cell (PASMC) proliferation. Although modern PH therapies have significantly improved survival, continued progress...
16.
Kang B, Park K, Kleinhenz J, Murphy T, Green D, Bijli K, et al.
Am J Respir Cell Mol Biol
. 2015 Jun;
54(1):136-46.
PMID: 26098770
Endothelin-1 (ET-1) plays a critical role in endothelial dysfunction and contributes to the pathogenesis of pulmonary hypertension (PH). We hypothesized that peroxisome proliferator-activated receptor γ (PPARγ) stimulates microRNAs that inhibit...
17.
Gray W, French K, Ghosh-Choudhary S, Maxwell J, Brown M, Platt M, et al.
Circ Res
. 2014 Oct;
116(2):255-63.
PMID: 25344555
Rationale: Myocardial infarction is a leading cause of death in developed nations, and there remains a need for cardiac therapeutic systems that mitigate tissue damage. Cardiac progenitor cells (CPCs) and...
18.
Alexy T, Rooney K, Weber M, Gray W, Searles C
Physiol Genomics
. 2014 Oct;
46(22):833-40.
PMID: 25315114
MicroRNAs (miRNAs) encapsulated within microparticles (MPs) are likely to have a role in cell-to-cell signaling in a variety of diseases, including atherosclerosis. However, little is known about the mechanisms by...
19.
Alexy T, James A, Searles C
Biorheology
. 2014 Jun;
51(2-3):147-58.
PMID: 24898334
Atherosclerosis, the leading cause of morbidity and mortality in developed nations, is a chronic inflammatory disease of arteries. In large and medium-sized vessels, the atherosclerotic burden is focal and non-random,...
20.
Weber M, Kim S, Patterson N, Rooney K, Searles C
Am J Physiol Heart Circ Physiol
. 2014 Feb;
306(8):H1192-203.
PMID: 24486510
Previously, we identified a microRNA (miRNA) signature for endothelial cells (ECs) subjected to unidirectional shear stress (USS). MiR-155, a multifunctional miRNA that has been implicated in atherosclerosis, was among the...